Applicability of cornea confocal microscopy in the diagnosis of small fiber neuropathy.
- Conditions
- small fiber neuropathie10034606
- Registration Number
- NL-OMON42708
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 225
Healthy subjects (n<=20)
a. Male and female subjects of 18 years or older
b. One or less positive answers on the SFN-SIQ
c. Written informed consent;Patients (n<=200):
Those who are referred to our center for the analysis of possible small fiber neuropathy are eligible for participation in this study.
Healthy subjects (n=20)
- Sensory symptoms in hands or feet or known with mono-/polyneuropathy.
- Known illnesses that can cause neuropathy, like diabetes mellitus, renal failure, alcohol abuse, rheumatoid arthritis, SLE, sarcoidosis, and thyroid dysfunction.
- History of diseases of the eye such as dry eyes, atopic keratoconjunctivitis, epithelial membrane basement dystrophies, cystic corneal disorders, which all affect corneal innervation.
- Patients with chronic glycemic exposure since this is a strong risk factor for corneal subbasal nerve loss.
- Use of medication (also in the past) known to possibly cause polyneuropathy.;Patients (n=200)
- History of diseases of the eye (such as mentioned above);Participants are excluded from this study when they do not want to be informed about defects or accidental findings which could be found during the pre-screening of the ophthalmologist.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL),<br /><br>and the tortuosity coefficient (CNFT) will be determined in all participants. </p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>