Effect of probiotics and/or synbiotics on intestinal environment in healthy adults.
- Conditions
- Healthy adults
- Registration Number
- JPRN-UMIN000029088
- Lead Sponsor
- Ezaki Glico Co., Ltd
- Brief Summary
1. The intestinal microbiota is modulated. 2. The Faecalibacterium ratio, Bifidobacterium ratio and number, as well as the amount of short-chain fatty acid in feces increase. 3. The effect on intestinal microbiota varies depending on the number of ingested bacteria.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 63
Not provided
1. Subjects regularly use intestinal drugs and laxatives (including strong laxatives). 2. Subjects habitually consume higher amount of alcohol. 3. Subjects who can't stop intake food containing bifidobacteria, and/or enhanced with oligosaccharide, dietary fiber during this study. 4. Subjects who have serious diseases requiring an urgent treatment, or who accept severe complication. 5. Subjects who have a medical history of diseases or surgeries affecting digestion, absorption and bowel movement. 6. Subjects who have allergy to test food. 7. Subjects who is pregnant or willing to be pregnant or breast-feeding during this study. 8. Subjects who are participated in other clinical trials that intake/apply any of food, drug, and cosmetics.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 16S rRNA gene based metagenome analysis of gut microbiome
- Secondary Outcome Measures
Name Time Method Fecal short chain fatty acid concentration, fecal bifidobacteria, defecation frequency