Effect of synbiotics on intestinal environment in healthy adults.

Not Applicable

• Conditions: Healthy adults

• Registration Number: JPRN-UMIN000031367
• Lead Sponsor: Ezaki Glico Co., Ltd

Brief Summary

The number of total bifidobacteria in feces was significantly increased during the probiotic and synbiotic intake periods compared with the observation period. There was no difference in the number of total bifidobacteria between the synbiotic intake period and the probiotic intake period (The average number of total bifidobacteria was higher in the symbiotic intake period compared to the probiotic intake period.). Moreover, the number of endogenous bifidobacteria was significantly higher in the synbiotic intake period compared to the probiotic intake period. By stratified analysis according to the number of B. lactis in the probiotic intake period (less than 5 X 10^9 cells/g), the number of total bifidobacteria, endogenous bifidobacteria and B. lactis was significantly higher in the symbiotic intake period compared to the probiotic intake period.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-04-12
• Study Start: 2019-04-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

1. Subjects regularly use intestinal drugs and laxatives (including strong laxatives). 2. Subjects habitually consume higher amount of alcohol. 3. Subjects who took in food containing and bifidobacteria, and/or enhanced with oligosaccharide, dietary fiber during one week prior to the start of this study and can't stop intake during this study. 4. Subjects who change their life styles during this clinical trial 5. Subjects who have serious diseases requiring an urgent treatment, or who accept severe complication. 6. Subjects who have a medical history of diseases or surgeries affecting digestion, absorption and bowel movement. 7. Subjects who have allergy to test food. 8. Subjects who is pregnant or willing to be pregnant or breast-feeding during this study. 9. Subjects who are participated in other clinical trials that intake/apply any of food, drug, and cosmetics.

Study & Design

• Study Type: Interventional
• Study Design: Not specified