A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age
- Conditions
- Cytomegalovirus Infection
- Interventions
- Biological: PlaceboBiological: mRNA-1647
- Registration Number
- NCT05085366
- Lead Sponsor
- ModernaTX, Inc.
- Brief Summary
The main purpose of this study is to evaluate the efficacy of mRNA 1647 vaccine in CMV-seronegative female participants and to evaluate the safety and reactogenicity of mRNA-1647 vaccine in all participants. The purpose of the Phase 3 extension sub study is to extend the observation period of the main study and to evaluate the longer-term immune persistence of mRNA-1647 vaccine administered to CMV-seronegative females who complete mRNA-1647-P301 main study and to assess for CMV seroconversion in CMV-seronegative participants who did not seroconvert during mRNA-1647-P301 main study. No interventional vaccine will be administered in the extension study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 7454
- Participants aged ≥20 years, has or anticipates having direct exposure within 7 months after the planned first dose (in the home, socially, or occupationally) to at least 1 child ≤5 years of age. Direct exposure is defined as either participant is the parent, or participant has close contact (feeding, diaper changes, childcare/supervision) for at least 8 hours per week.
- CMV-seronegative Cohort is CMV-seronegative based on CMV testing at Screening.
- CMV-seropositive Cohort is CMV-seropositive based on CMV testing at Screening.
- Investigator assessment confirms that the participant (including in the case of an emancipated minor), or parent(s)/legally acceptable representative (LAR)(s), as applicable, understand and are willing and physically able to comply with protocol-mandated follow-up including all study visits and procedures anticipated during the 30 month study period.
- Female participants of child-bearing potential: Urine pregnancy test is negative at Screening and negative on the day of the first injection (Day 1). If the participant is sexually active with men, has practiced adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to the first injection (Day 1) and agrees to continue adequate contraception through 3 months following the third study injection (Month 9/Day 257).
Extension substudy:
- All consenting participants in mRNA-1647-P301 main study who were CMV-seronegative at baseline and did not seroconvert during the main study, received at least one injection of either mRNA-1647 or placebo, and completed the final study visit in the main study.
- Consenting participants in mRNA-1647-P301 main study who were CMV-seropositive at baseline, received all 3 study injections, and completed the final study visit in the main study.
Key
- History of a diagnosis or condition that, in the judgment of the Investigator, is clinically unstable or may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures.
- Received or plans to receive any nonstudy vaccine <28 days prior to and after any study injection; in addition, the following criteria for COVID-19 and influenza vaccines apply:
- Any COVID-19 primary vaccination series must have been completed a minimum 28 days prior to receiving any dose of the study injection.
- COVID-19 vaccines (including any booster dose, regardless of manufacturer) must be administered at least 28 days prior to or after any study injection.
- Influenza vaccines may be administered > 14 days prior to or after any study injection.
- Received systemic immunosuppressants or immune-modifying drugs for >14 days in total within 6 months prior to the day of first injection (Day 1) (for corticosteroids, ≥5 milligrams (mg)/day of prednisone equivalent) or plans to do so during the course of the study. Inhaled, nasal, and topical steroids are allowed. Stable immunomodulator regimens used for managing environmental allergies are allowed.
- Receipt of an antiviral with activity against CMV (ganciclovir, valganciclovir, foscarnet, cidofovir, letermovir, acyclovir, valacyclovir) <2 weeks prior to the day of first injection or plans to do so during the course of the study.
- Previous receipt of an investigational CMV vaccine.
- Receipt of systemic immunoglobulins or blood products <3 months prior to the day of first injection.
- Participated in an interventional clinical study <28 days prior to the day of first injection (Day 1) or plans to do so while enrolled in this study.
- Participant has donated ≥450 milliliters (mL) of blood products <28 days prior to Screening.
- Participant is a member of study team or is an immediate family member or household member of study personnel.
Extension substudy:
- Receipt of any CMV vaccine other than mRNA-1647.
- Diagnosis or condition that, in the judgment of the Investigator, may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures, including any medical, psychiatric, or occupational condition that, in the opinion of the Investigator, might pose additional risk due to participation in the study or could interfere with the interpretation of study results.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Participants will receive mRNA-1647 vaccine matching placebo by IM injection on Day 1, Day 57, and Day 169. mRNA-1647 mRNA-1647 Participants will receive mRNA-1647 vaccine by intramuscular (IM) injection on Day 1, Day 57, and Day 169.
- Primary Outcome Measures
Name Time Method Seroconversion From a Negative to a Positive Result for Serum Immunoglobulin G (IgG) Against Antigens not Encoded by mRNA-1647 Day 197 (28 days after the third injection) up to Day 887 (24 months after the third injection) Seroconversion From a Negative to a Positive Result for Serum IgG Against Antigens not Encoded by mRNA-1647 Day 887 up to Day 1607 Number of Participants With Unsolicited Adverse Events (AEs) Up to 197 days (28 days after each injection) Geometric Mean Concentration (GMC) of Binding Antibody Month 30 up to Month 54 Number of Participants With Adverse Event of Special Interests (AESIs) and Serious Adverse Events (SAEs) Day 1 through Day 887 Number of Participants With Solicited Adverse Reactions (ARs) Up to 176 days (7 days after each injection) Geometric Mean Titers (GMTs) of Antigen-Specific Neutralizing Antibody (nAb) Month 30 up to Month 54 Number of Participants With Medically-Attended Adverse Events (MAAEs) Day 1 through 6 months after the last injection (up to 347 days)
- Secondary Outcome Measures
Name Time Method GMC of Antigen-Specific Binding Antibody Day 1, Months 3, 7, 12, 18, 24, and 30 GMTs of Antigen-Specific nAb Day 1, Months 3, 7, 12, 18, 24, and 30 Number of Participants with AEs leading to Study Discontinuation, SAEs and Deaths Day 887 through end of study (up to Day 1607)
Trial Locations
- Locations (278)
CVS HealthHub - Atlanta S
🇺🇸Atlanta, Georgia, United States
CVS HealthHub - Atlanta
🇺🇸Atlanta, Georgia, United States
Aventiv Research Inc.
🇺🇸Columbus, Ohio, United States
WellNow Urgent Care & Research - Huber Heights
🇺🇸Columbus, Ohio, United States
Velocity Clinical Research - Medford
🇺🇸Medford, Oregon, United States
Boeson Research MSO - Missoula
🇺🇸Missoula, Montana, United States
Voyage Medical
🇺🇸Tempe, Arizona, United States
Floridian Clinical Research - ClinEdge - PPDS
🇺🇸Miami Lakes, Florida, United States
Precision Clinical Research - Plantation
🇺🇸Plantation, Florida, United States
SPICA Clinical Research
🇺🇸Columbia, South Carolina, United States
Centricity Research - Toronto
🇨🇦Toronto, Ontario, Canada
William Harvey Clinical Research Centre
🇬🇧London, England, United Kingdom
St George s Vaccine Institute
🇬🇧London, England, United Kingdom
Clinical trial site
🇯🇵Osaka-shi Osaka, Kansai, Japan
Boeson Research GTF - Great Falls
🇺🇸Great Falls, Montana, United States
Soroka University Medical Centre
🇮🇱Beer Sheva, Tel Aviv District, Israel
Universal Axon Clinical Research
🇺🇸Doral, Florida, United States
Emerald Coast OBGYN Clinical Research
🇺🇸Panama City, Florida, United States
Velocity Clinical Research
🇺🇸West Jordan, Utah, United States
ASHA Clinical Research - ClinEdge
🇺🇸Hammond, Indiana, United States
Del Pilar Medical and Urgent Care
🇺🇸Mishawaka, Indiana, United States
Great Lakes Research Institute
🇺🇸Southfield, Michigan, United States
Meridian Clinical Research (Hastings, Nebraska)
🇺🇸Hastings, Nebraska, United States
Be Well Clinical Studies, LLC - Lincoln - ERN - PPDS
🇺🇸Lincoln, Nebraska, United States
Lillestol Research
🇺🇸Fargo, North Dakota, United States
CCBR Clinical Research
🇪🇪Tallinn, Harjumaa, Estonia
Tampereen Rokotetutkimusklinikka
🇫🇮Tampere, Pirkanmaa, Finland
Seattle Clinical Research Center
🇺🇸Seattle, Washington, United States
Clinical Research Center Of Nevada
🇺🇸Las Vegas, Nevada, United States
Florida International Medical Research
🇺🇸Miami, Florida, United States
Miami Clinical Research
🇺🇸Miami, Florida, United States
Spotlight Research Center, LLC
🇺🇸Miami, Florida, United States
Trio Clinical Trials LLC
🇺🇸Houston, Texas, United States
New Horizon Medical Group, LLC
🇺🇸Houston, Texas, United States
Womens Healthcare Research Corporation ERN PPDS
🇺🇸San Diego, California, United States
CTI Clinical Research Center - ClinEdge - PPDS
🇺🇸Cincinnati, Ohio, United States
University of Cincinnati Medical Center-Goodman St
🇺🇸Cincinnati, Ohio, United States
Frauenarztpraxis Erwin Göckeler-Leopold
🇩🇪Geseke, North Rhine-Westphalia, Germany
RED-Institut GmbH
🇩🇪Oldenburg in Holstein, Schleswig-Holstein, Germany
Praxis Reinfeld-Mitte
🇩🇪Reinfeld, Schleswig-Holstein, Germany
Porin Rokotetutkimusklinikka
🇫🇮Pori, Satakunta, Finland
Accel Research Site - Achieve - Birmingham - ERN - PPDS
🇺🇸Birmingham, Alabama, United States
Wayne State University
🇺🇸Detroit, Michigan, United States
Clinical Research Institute, Inc - CRN - PPDS
🇺🇸Minneapolis, Minnesota, United States
University of Minnesota Clinical Research Unit
🇺🇸Minneapolis, Minnesota, United States
Lynn Health Science Institute
🇺🇸Oklahoma City, Oklahoma, United States
Quality Clinical Research
🇺🇸Omaha, Nebraska, United States
Meridian Clinical Research-(Omaha Nebraska)
🇺🇸Omaha, Nebraska, United States
Foothill Family Clinic
🇺🇸Salt Lake City, Utah, United States
Foothill Family Clinic - South Clinic
🇺🇸Salt Lake City, Utah, United States
Care Access Research - Aurora
🇺🇸Aurora, Colorado, United States
University of Colorado Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
Tampa Bay Health Care
🇺🇸Tampa, Florida, United States
Meir Medical Center
🇮🇱Kfar Saba, Israel
Central Research Associates Inc
🇺🇸Birmingham, Alabama, United States
SEC Clinical Research LLC - Dothan - ClinEdge - PPDS
🇺🇸Dothan, Alabama, United States
Arizona Clinical Trials
🇺🇸Mesa, Arizona, United States
Lakeview Clinical Research
🇺🇸Guntersville, Alabama, United States
Chandler Clinical Trials, LLC
🇺🇸Chandler, Arizona, United States
MedPharmics, LLC
🇺🇸Gulfport, Mississippi, United States
Epic Medical Research Arizona
🇺🇸Surprise, Arizona, United States
Hope Research Institute LLC
🇺🇸Tempe, Arizona, United States
Phoenix Clinical LLC
🇺🇸Phoenix, Arizona, United States
The Institute for Liver Health-Tucson
🇺🇸Tucson, Arizona, United States
Del Sol Research Management - ClinEdge - PPDS
🇺🇸Tucson, Arizona, United States
Tucson Neuroscience Research - M3 WR - ERN - PPDS
🇺🇸Tucson, Arizona, United States
Noble Clinical Research
🇺🇸Tucson, Arizona, United States
Preferred Research Partners
🇺🇸Little Rock, Arkansas, United States
Baptist Health Center for Clinical Research
🇺🇸Little Rock, Arkansas, United States
Velocity Clinical Research - Banning
🇺🇸Banning, California, United States
Applied Research Center of Arkansas - Clinedge - PPDS
🇺🇸Little Rock, Arkansas, United States
Ascada Research LLC
🇺🇸Fullerton, California, United States
Velocity Clinical Research - Chula Vista
🇺🇸Chula Vista, California, United States
Paradigm Clinical Research Center
🇺🇸La Mesa, California, United States
Apex Research Group
🇺🇸Fair Oaks, California, United States
Long Beach Research Institute, LLC
🇺🇸Long Beach, California, United States
Long Beach Clinical Trials Services Inc.
🇺🇸Long Beach, California, United States
Catalina Research Institute LLC
🇺🇸Montclair, California, United States
Empire Clinical Research
🇺🇸Pomona, California, United States
Carbon Health- NoHo West Urgent Care and Primary Care
🇺🇸North Hollywood, California, United States
Paradigm Clinical Research Institute, Inc. - ClinEdge
🇺🇸Redding, California, United States
Smart Cures Clinical Research
🇺🇸Rolling Hills Estates, California, United States
Care Access Research - Santa Clarita
🇺🇸Santa Clarita, California, United States
Stanford University School of Medicine
🇺🇸Stanford, California, United States
Bayview Research Group
🇺🇸Valley Village, California, United States
Clinical Trials Management Services, LLC
🇺🇸Thousand Oaks, California, United States
Next Level Clinical Trials
🇺🇸West Covina, California, United States
Invictus Clinical Research Group, LLC
🇺🇸Coconut Creek, Florida, United States
Paradigm Clinical Research Institute Inc - ClinEdge
🇺🇸Wheat Ridge, Colorado, United States
Clinical Research Consultants LLC
🇺🇸Milford, Connecticut, United States
New England Research Associates LLC - ERN - PPDS
🇺🇸Bridgeport, Connecticut, United States
Luna Research LLC
🇺🇸Coral Gables, Florida, United States
Emerson Clinical Research Institute LLC - Kennedy St
🇺🇸Washington, District of Columbia, United States
Herco Medical and Research Center, Inc.
🇺🇸Coral Gables, Florida, United States
Precision Clinical Research, LLC
🇺🇸Coral Springs, Florida, United States
Unique Clinical Trials, LLC
🇺🇸Doral, Florida, United States
Indago Research and Health Center
🇺🇸Hialeah, Florida, United States
Velocity Clinical Research, New Smyrna Beach
🇺🇸Edgewater, Florida, United States
Best Quality Research, Inc
🇺🇸Hialeah, Florida, United States
Ideal Clinical Research, Inc. - ClinEdge - PPDS
🇺🇸Pembroke Pines, Florida, United States
Ormond Beach Clinical Research
🇺🇸Ormond Beach, Florida, United States
GCP Global Clinical Professionals
🇺🇸Saint Petersburg, Florida, United States
CVS HealthHub - Dacula
🇺🇸Dacula, Georgia, United States
Tekton Research - Georgia - Platinum
🇺🇸Chamblee, Georgia, United States
IResearch Atlanta LLC
🇺🇸Decatur, Georgia, United States
Centricity Research - Roswel
🇺🇸Columbus, Georgia, United States
CVS HealthHub - Kennesaw
🇺🇸Kennesaw, Georgia, United States
Drug Studies America - ClinEdge - PPDS
🇺🇸Marietta, Georgia, United States
CVS HealthHub - Newman
🇺🇸Newnan, Georgia, United States
CVS HealthHub - Mcdonough
🇺🇸McDonough, Georgia, United States
Mount Vernon Clinical Research, LLC - M3 WR - ERN - PPDS
🇺🇸Sandy Springs, Georgia, United States
One Health Research Clinic, Inc.
🇺🇸Norcross, Georgia, United States
CVS HealthHub - Savannah
🇺🇸Savannah, Georgia, United States
Clinical Research Prime - Clinedge
🇺🇸Idaho Falls, Idaho, United States
Optimal Research
🇺🇸Peoria, Illinois, United States
Affinity Health
🇺🇸Oak Brook, Illinois, United States
Velocity Clinical Research - Covington
🇺🇸Metairie, Louisiana, United States
Skylight Health Research - Burlington
🇺🇸Burlington, Massachusetts, United States
Meridian Clinical Research-(Rockville Maryland)
🇺🇸Rockville, Maryland, United States
Centennial Medical Group - Elkridge - Rx Trials
🇺🇸Elkridge, Maryland, United States
ActivMed Practices & Research Inc
🇺🇸Methuen, Massachusetts, United States
DM Clinical Research - The Brook House
🇺🇸Brookline, Massachusetts, United States
Voyage Medical - Michigan
🇺🇸Canton, Michigan, United States
DM Clinical Research - Southfield
🇺🇸Southfield, Michigan, United States
MediSync Clinical Research Hattiesburg Clinic
🇺🇸Petal, Mississippi, United States
Boeson Research KAL - Kalispell - ERN - PPDS
🇺🇸Kalispell, Montana, United States
Meridian Clinical Research (Grand Island, Nebraska)
🇺🇸Grand Island, Nebraska, United States
Meridian Clinical Research (Norfolk-Nebraska)
🇺🇸Norfolk, Nebraska, United States
Med Clinic Research Partners, LLC
🇺🇸Irvington, New Jersey, United States
WellNow Urgent Care Clinical Research
🇺🇸E. Amherst, New York, United States
SUNY Upstate Medical Center
🇺🇸Syracuse, New York, United States
OnSite Clinical Solutions, LLC
🇺🇸Charlotte, North Carolina, United States
Meridian Clinical Research (Endwell-New York) - Platinum - PPDS
🇺🇸Binghamton, New York, United States
Rochester Clinical Research, Inc
🇺🇸Rochester, New York, United States
Carolina Institute for Clinical Research - M3 WR - ERN - PPDS
🇺🇸Fayetteville, North Carolina, United States
Monroe Biomedical Research (Venus St)
🇺🇸Monroe, North Carolina, United States
Lucas Research
🇺🇸Morehead City, North Carolina, United States
Meridian Cincinnati
🇺🇸Cincinnati, Ohio, United States
ClinOhio Research Services
🇺🇸Columbus, Ohio, United States
PriMed Clinical Research - ClinEdge
🇺🇸Dayton, Ohio, United States
Epic Medical Research Oklahoma
🇺🇸Chickasha, Oklahoma, United States
Senders Pediatrics
🇺🇸South Euclid, Ohio, United States
PMG Research of Charleston LLC
🇺🇸Mount Pleasant, South Carolina, United States
Tekton Research - Oklahoma - Platinum
🇺🇸Yukon, Oklahoma, United States
Coastal Carolina Research Center
🇺🇸North Charleston, South Carolina, United States
Tekton Research - Beaumont
🇺🇸Beaumont, Texas, United States
Gadolin Research LLC
🇺🇸Beaumont, Texas, United States
Global Medical Research
🇺🇸Dallas, Texas, United States
REX Clinical Trials
🇺🇸Beaumont, Texas, United States
Velocity Clinical Research - Austin
🇺🇸Cedar Park, Texas, United States
Zenos Clinical Research
🇺🇸Dallas, Texas, United States
ANRC Research
🇺🇸El Paso, Texas, United States
Village Health Partners Frisco Medical Village
🇺🇸Frisco, Texas, United States
Vilo Research Group, L.L.C.
🇺🇸Houston, Texas, United States
Cedar Health Research - Fort Worth - PPDS
🇺🇸Irving, Texas, United States
Helios CCR, Inc.-keller-PPDS
🇺🇸Keller, Texas, United States
University of Texas Medical Branch - Bay Colony, SIVS Clinical Trials Program
🇺🇸League City, Texas, United States
BRCR Medical Center Inc - McAllen
🇺🇸McAllen, Texas, United States
Synergy Group US, LLC
🇺🇸Missouri City, Texas, United States
Austin Regional Clinic ARC Clinical Research at Kelly Lane
🇺🇸Pflugerville, Texas, United States
GLRI McAllen Research
🇺🇸Pharr, Texas, United States
ACRC Trials - Independence Parkway - Plano - Hunt - PPDS
🇺🇸Plano, Texas, United States
Clinical Trials of Texas, Inc. - HyperCor
🇺🇸San Antonio, Texas, United States
Diagnostics Research Group
🇺🇸San Antonio, Texas, United States
Epic Medical Research LLC
🇺🇸Red Oak, Texas, United States
DM Clinical Research
🇺🇸Tomball, Texas, United States
ClinPoint Trials LLC
🇺🇸Waxahachie, Texas, United States
Crossroads Clinical Research (Victoria)
🇺🇸Victoria, Texas, United States
Granger Medical Clinic - Riverton
🇺🇸Riverton, Utah, United States
Tanner Clinic
🇺🇸Layton, Utah, United States
York Clinical Research
🇺🇸Norfolk, Virginia, United States
Health Research of Hampton Roads Inc. - ClinEdge
🇺🇸Newport News, Virginia, United States
David Ramstad Associates Research - IACT - HyperCore - PPDS
🇺🇸Suffolk, Virginia, United States
Rainier Clinical Research Center
🇺🇸Renton, Washington, United States
Velocity Clinical Research - Spokane - PPDS
🇺🇸Spokane, Washington, United States
Paratus Clinical Research
🇦🇺Bruce, Australian Capital Territory, Australia
Kanwal Medical Complex
🇦🇺Kanwal, New South Wales, Australia
Paratus Clinical Research - Western Sydney
🇦🇺Blacktown, New South Wales, Australia
University of the Sunshine Coast, Health Hub Morayfield
🇦🇺Morayfield, Queensland, Australia
Northern Beaches Clinical Research
🇦🇺Brookvale, New South Wales, Australia
Emeritus Research
🇦🇺Camberwell, Victoria, Australia
Northside Health
🇦🇺Coffs Harbour, New South Wales, Australia
Hunter Diabetes Centre
🇦🇺Merewether, New South Wales, Australia
University of the Sunshine Coast
🇦🇺Sippy Downs, Queensland, Australia
USC Southbank
🇦🇺Southbank, Queensland, Australia
Barwon Health
🇦🇺Geelong, Victoria, Australia
The University of Melbourne
🇦🇺Melbourne, Victoria, Australia
CHU de Liège
🇧🇪Liège, Belgium
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Center for Vaccinology (CEVAC)
🇧🇪Gent, Oost-Vlaanderen, Belgium
AZ Sint-Lucas Brugge
🇧🇪Brugge, West-Vlaanderen, Belgium
Telethon Kids Institute
🇦🇺Nedlands, Western Australia, Australia
Ottawa Hospital
🇨🇦Ottawa, Ontario, Canada
LMC Manna Research - Burlington - HyperCore - PPDS
🇨🇦Burlington, Ontario, Canada
Canadian Center for Vaccinology
🇨🇦Halifax, Nova Scotia, Canada
Dr. Anil K. Gupta Medicine Professional Corporation
🇨🇦Toronto, Ontario, Canada
Bluewater Clinical Research Group
🇨🇦Sarnia, Ontario, Canada
Centricity Research - Quebec - HyperCore - PPDS
🇨🇦Levis, Quebec, Canada
Centricity Research - Mirabel - HyperCore - PPDS
🇨🇦Mirabel, Quebec, Canada
McGill University Health Center
🇨🇦Montreal, Quebec, Canada
McGill University Health Centre-Vaccine Study Centre
🇨🇦Pierrefonds, Quebec, Canada
Centricity Research - Montreal - HyperCore - PPDS
🇨🇦Pointe-Claire, Quebec, Canada
Diex Recherche - Québec - HyperCore
🇨🇦Québec City, Quebec, Canada
Diex Recherche - Joilette - HyperCore - PPDS
🇨🇦Saint-Charles-Borromée, Quebec, Canada
Diex Recherche - Sherbrooke - HyperCore
🇨🇦Sherbrooke, Quebec, Canada
Diex Recherche - Victoriaville - HyperCore
🇨🇦Victoriaville, Quebec, Canada
Al Mare Family Doctors Centre
🇪🇪Tallinn, Harjumaa, Estonia
Tampereen Yliopisto Seinajoen Rokotusklinikka
🇫🇮Seinäjoki, Etelä-Pohjanmaa, Finland
CHU Montpellier - Hôpital St Eloi
🇫🇷Montpellier, France
Merelahe Family Doctors Centre
🇪🇪Tallinn, Harjumaa, Estonia
Vee Family Doctors Center Ltd
🇪🇪Paide, Järvamaa, Estonia
Clinical Research Centre Ltd.
🇪🇪Tartu, Tartumaa, Estonia
Etelä Helsingin Rokotetutkimusklinikka
🇫🇮Helsinki, Etelä-Suomen Lään, Finland
Oulun Rokotetutkimusklinikka
🇫🇮Oulu, Oulun Lääni, Finland
Kokkolan Rokotetutkimusklinikka
🇫🇮Kokkola, Keski-Pohjanmaa, Finland
Espoon rokotetutkimusklinikka
🇫🇮Espoo, Uusimaa, Finland
CHRU Nantes
🇫🇷Nantes, Pays De La Loire, France
Järvenpään Rokotetutkimusklinikka
🇫🇮Järvenpää, Uusimaa, Finland
Turun Rokotetutkimusklinikka
🇫🇮Turku, Västra Finlands Län, Finland
Itä Helsingin Rokotetutkimusklinikka
🇫🇮Helsinki, Uusimaa, Finland
Centre Hospitalier et Universitaire de Limoges
🇫🇷Limoges, France
Centre Hospitalier Departemental de Vendee
🇫🇷La Roche-sur-Yon, France
Hopital Necker
🇫🇷Paris, France
Groupe Hospitalier Cochin Saint Vincent de Paul
🇫🇷Paris, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre Bénite, France
Centre Hospitalier Universitaire de Saint Etienne
🇫🇷Saint-Priest-en-Jarez, France
CHRU de Tours
🇫🇷Tours, France
TriDerm
🇩🇪Stuttgart, Baden-Württemberg, Germany
Universitätsklinikum Bonn
🇩🇪Bonn, Nordrhein-Westfalen, Germany
Klifeck GmbH
🇩🇪Delitzsch, Sachsen, Germany
Dermatologie Quist
🇩🇪Mainz, Rhineland-Palatinate, Germany
Berliner Centrum für Reise- und Tropenmedizin BCRT GmbH
🇩🇪Berlin, Germany
Velocity Clinical Research - Hamburg - PPDS
🇩🇪Hamburg, Germany
Bernhard Nocht Centre for Clinical Trials (BNCCT)am Bernhard-Nocht-Institut für Tropenmedizin
🇩🇪Hamburg, Germany
Office of Klaus H. Peters, Dr.med
🇩🇪Hamburg, Germany
AmBeNet GmbH
🇩🇪Leipzig, Germany
Centrum Für Diagnostik und Gesundheit
🇩🇪München, Germany
Sheba Medical Center - PPDS
🇮🇱Petah Tiqva, Central District Of Israel, Israel
Velocity Clniical Research Leipzip Gmbh
🇩🇪Leipzig, Germany
Medislim GmbH - Zentrum fuer Ambulante Klinische Forschung
🇩🇪Weinheim, Germany
Rambam Medical Center - PPDS
🇮🇱Haifa, Haifa Hefa, Israel
Shamir Medical Center Assaf Harofeh
🇮🇱Beer Yaakov, Rishon Lezion, Israel
Maccabi Hashalom
🇮🇱Tel Aviv, Tel Aviv District, Israel
Hadassah Medical Center - PPDS
🇮🇱Jerusalem, Yerushalayim Al Quds, Israel
Rabin Medical Center
🇮🇱Petah-Tikva, Israel
Tel Aviv Sourasky Medical Center PPDS
🇮🇱Tel-Aviv, Israel
Ospedale Policlinico San Martino
🇮🇹Genova, Italy
Fondazione IRCCS San Gerardo dei Tintori - MBBM - c/o Centro Maria Letizia Verga
🇮🇹Monza, Italy
C.H. Regional Reina Sofia
🇪🇸Cordoba, Andalusia, Spain
Clinical Trial Site
🇯🇵Taito-ku, Tokyo, Japan
Kobe University Hospital
🇯🇵Kobe-Shi, Hyôgo, Japan
Hospital Quironsalud Malaga
🇪🇸Malaga, Andalusia, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Catalonia, Spain
ABS Centelles
🇪🇸Centelles, Catalonia, Spain
Instituto Hispalense de Pediatria
🇪🇸Sevilla, Andalusia, Spain
Hospital HM Puerta del Sur
🇪🇸Mostoles, Madrird, Spain
CHUS - H. Clinico U. de Santiago
🇪🇸Santiago de Compostela, Galicia, Spain
The James Cook University Hospital
🇬🇧Middlesbrough, Cleveland, United Kingdom
NIHR Patient Recruitment Centre: Newcastle
🇬🇧Newcastle upon Tyne, Northumberland, United Kingdom
Lakeside Surgery
🇬🇧Corby, Northamptonshire, United Kingdom
St Michaels Hospital
🇬🇧Bristol, South West England, United Kingdom
NIHR Clinical Research Facility, University Hospital Southampton NHS Foundation Trust
🇬🇧Southampton, United Kingdom
Hospital Universitario La Paz.
🇪🇸Madrid, Spain
Shaare Zedek Medical Center
🇮🇱Jerusalem, Yerushalayim Al Quds, Israel
M3 Wake Research, Inc - M3 WR - ERN - PPDS
🇺🇸Raleigh, North Carolina, United States
Northern California Research Corp
🇺🇸Sacramento, California, United States
ARC Clinical Research at Wilson Parke
🇺🇸Austin, Texas, United States
ARC Clinical Research at William Cannon
🇺🇸Austin, Texas, United States
Premier Family Physicians - Austin - Hunt
🇺🇸Austin, Texas, United States
Tekton Research, Inc.
🇺🇸Austin, Texas, United States
Iowa Clinic
🇺🇸Des Moines, Iowa, United States
Alliance for Multispecialty Research, LLC
🇺🇸Lexington, Kentucky, United States
Albuquerque Clinical Trials Inc.
🇺🇸Albuquerque, New Mexico, United States
MedPharmics, LLC. - Albuquerque
🇺🇸Albuquerque, New Mexico, United States
University Of Wisconsin - Madison
🇺🇸Madison, Wisconsin, United States
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
Johnson Country Clin-Trials
🇺🇸Lenexa, Kansas, United States
Velocity Clinical Research - San Diego
🇺🇸La Mesa, California, United States
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