Comparison of High Flow Nasal Cannula vs Nasal Cannula in Mild Chronic Obstructive Pulmonary Disease Exacerbation(AECOPD)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 328
- 试验地点
- 1
- 主要终点
- endotracheal intubation demand rate
研究概览
简要总结
For AECOPD patients, only 8% patients ventilated by noninvasive and invasive positive pressure ventilation. Nasal cannula is the most common pattern of oxygen therapy in mild AECOPD. As a low flow oxygen therapy, nasal cannula has many disadvantages.Therefore, we design a randomized controlled trial(RCT)to explore whether HFNC would be better than nasal cannula to prevent the aggravation of respiratory failure and endotracheal intubation in mild AECOPD.
详细描述
For AECOPD patients, most of patients don't need respiratory support, only 8% patients ventilated by noninvasive and invasive positive pressure ventilation. Nasal cannula is the most common pattern of oxygen therapy in mild AECOPD. As a low flow oxygen therapy, nasal cannula has many disadvantages: discomfort, low humidity and unstable fraction of inspired oxygen(FiO2) in inspiratory gas. Therefore, we design a RCT to explore whether HFNC would be better than nasal cannula to prevent the aggravation of respiratory failure and endotracheal intubation in mild AECOPD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AECOPD; pH≥7.35, PaCO2>45 mmHg
排除标准
- •Need to be intubated immediately; refuse to engage in the study; severe organ dysfunction
研究组 & 干预措施
High flow nasal cannula
High flow nasal cannula(OptiflowTM); Flow 25-60 L/min is set according to patients' comfort; FiO2 is adjusted to maintain peripheral capillary oxygen saturation(SpO2) 90-95%; temperature is set at 37.
干预措施: High flow nasal cannula (Device)
Nasal cannula
Nasal cannula;set oxygen flow to keep SpO2 90-95%
结局指标
主要结局
endotracheal intubation demand rate
时间窗: 90days
次要结局
- actual endotracheal intubation rate(90days)
研究者
Qingyuan Zhan
head of Pulmonary and Critical care medicine ward 4
China-Japan Friendship Hospital