A Comparison of Zidovudine (AZT) and Stavudine in HIV-Infected Patients
- Conditions
- HIV Infections
- Registration Number
- NCT00002307
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
To compare stavudine (d4T) and zidovudine (AZT) in slowing the progression of HIV disease. To compare the antiviral activity of d4T versus AZT as measured by plasma levels of p24 antigen and HIV viremia, and their relative efficacy by improvement and/or absence of adverse changes over time in laboratory parameters associated with HIV infection. To compare the safety of oral doses of d4T to AZT in patients with HIV infection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (45)
SUNY / Health Sciences Ctr at Stony Brook
🇺🇸Stony Brook, New York, United States
East Bay AIDS Ctr
🇺🇸Berkeley, California, United States
Children's Hosp of Los Angeles
🇺🇸Los Angeles, California, United States
Combat Group
🇺🇸Los Angeles, California, United States
TheraFirst Med Ctrs Inc
🇺🇸Fort Lauderdale, Florida, United States
Los Angeles County - USC Med Ctr
🇺🇸Los Angeles, California, United States
Chase Braxton Health Service
🇺🇸Baltimore, Maryland, United States
Buckley Braffman Stern Med Associates
🇺🇸Philadelphia, Pennsylvania, United States
Univ of Texas Southwestern Med Ctr of Dallas
🇺🇸Dallas, Texas, United States
Houston Clinical Research Network
🇺🇸Houston, Texas, United States
Univ of Miami
🇺🇸Miami, Florida, United States
Infectious Diseases Research Clinic / Indiana Univ Hosp
🇺🇸Indianapolis, Indiana, United States
Duke Univ Med Ctr
🇺🇸Durham, North Carolina, United States
Univ TX San Antonio Health Science Ctr
🇺🇸San Antonio, Texas, United States
Univ of Kansas School of Medicine / Univ Hosp
🇺🇸Kansas City, Kansas, United States
Univ of Kansas School of Medicine
🇺🇸Wichita, Kansas, United States
Harbor UCLA Med Ctr
🇺🇸Torrance, California, United States
Univ of Arizona / Health Science Ctr
🇺🇸Tucson, Arizona, United States
Cedars Sinai Med Ctr
🇺🇸Los Angeles, California, United States
UCD Med Ctr / AIDS and Related Disorders Clinic
🇺🇸Sacramento, California, United States
Children's Hosp of San Francisco
🇺🇸San Francisco, California, United States
Univ of Colorado Health Sciences Ctr
🇺🇸Denver, Colorado, United States
Whitman - Walker Clinic
🇺🇸Washington, District of Columbia, United States
George Washington Univ Med Ctr
🇺🇸Washington, District of Columbia, United States
Community Research Initiative of South Florida
🇺🇸Coral Gables, Florida, United States
Infectious Disease Research Institute Inc
🇺🇸Tampa, Florida, United States
Dr Steven Marlowe
🇺🇸Atlanta, Georgia, United States
Northwestern Univ Med School
🇺🇸Chicago, Illinois, United States
Rush Presbyterian - Saint Luke's Med Ctr
🇺🇸Chicago, Illinois, United States
Univ of New Mexico School of Medicine
🇺🇸Albuquerque, New Mexico, United States
Bronx Veterans Affairs Med Ctr
🇺🇸Bronx, New York, United States
New England Deaconess Hosp
🇺🇸Boston, Massachusetts, United States
Univ of Nebraska Med Ctr / HIV Clinic
🇺🇸Omaha, Nebraska, United States
Cornell Univ Med College
🇺🇸New York, New York, United States
Beth Israel Med Ctr
🇺🇸New York, New York, United States
Saint Luke's - Roosevelt Hosp Ctr
🇺🇸New York, New York, United States
Univ of Pennsylvania / HIV Clinic
🇺🇸Philadelphia, Pennsylvania, United States
Med Univ of South Carolina
🇺🇸Charleston, South Carolina, United States
Mount Sinai Med Ctr
🇺🇸New York, New York, United States
Montefiore Hosp
🇺🇸Pittsburgh, Pennsylvania, United States
Nalle Clinic
🇺🇸Charlotte, North Carolina, United States
Dr Edward Stool
🇺🇸Houston, Texas, United States
Univ of Utah School of Medicine
🇺🇸Salt Lake City, Utah, United States
UPR School of Medicine / San Juan Veterans Adm Med Ctr
🇵🇷San Juan, Puerto Rico
Milwaukee County Med Complex
🇺🇸Milwaukee, Wisconsin, United States