High-field Brain Magnetic Resonance Spectroscopy
- Conditions
- Healthy
- Registration Number
- NCT02053701
- Lead Sponsor
- University of Minnesota
- Brief Summary
Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").
The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla).
Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision.
Aims
1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla).
2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).
Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 30
- over 18 years old
- no metallic implant or other MRI-incompatible device
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Precision of quantification of brain metabolites concentrations One time only This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Center for Magnetic Resonance Research
🇺🇸Minneapolis, Minnesota, United States