Effect of vancomycin plus rifampicin in the treatment on methicillin-resistant Staphylococcus aureus pneumonia

Not Applicable

Recruiting

• Conditions: Diseases of th respiratory system

• Registration Number: KCT0000029
• Lead Sponsor: Asan Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 266

Inclusion Criteria

Adult patients = 18 years of age will be screened daily for clinical signs and symptoms
consistent with nosocomial pneumonia, i.e., one developed 48 h or later after admission.: had to meet two criteria (a,b)

a. A patient had to have a chest radiograph consistent with the diagnosis of pneumonia (new or
persistent radiographic infiltrates(new or progressive infiltrates, consolidation, with/without
pleural effusion
b. Modified CPIS (clinical pulmonary infection score) = 4

Exclusion Criteria

a.presence ofmeningitis, endocarditis, or osteomyelitis
b.bone marrow tranplantation or organ transplantation
c.vancomycin treatment for = 48 h for any reason in the preceding week;
d.elevated liver enzymes (= 3 times the upper limits of normal) or total bilirubin = 3.0 mg/dL
e.severe neutropenia (< 1000 cells /mm3) or human immunodeficiency virus infection
f.chemotherapy or persistent immunosuppression is needed
g.a pathogen resistant to RFP or vancomycin

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical cure rate

Secondary Outcome Measures

Name	Time	Method
microbiologic eradication;Mortality rate