The loss of gut wall integrity through non-abdominal surgical trauma in adults, children and neonates

Completed

Conditions: complications after major surgery
inflammtion
10017969
10009720

Registration Number: NL-OMON30582

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Children and adults undergoing major spinal surgery and neonates undergoing thoracotomy in the University Hospital Maastricht.
Patients that have an arterial line or central venous access to facilitate plasma
sampling.
Patients that have given informed consent

Exclusion Criteria

Patients who have any other cause for gut damage, such as inflammation (eg active inflammatory bowel disease), direct surgical trauma (eg abdominal surgery), or artificial circulation (eg cardiopulmonary bypass).

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>As first outcome measurement, this study will evaluate the origin of intestinal<br /><br>epithelial cell damage, mucosal hypoperfsuion, inflammation, bacterial<br /><br>translocation and postoperative complications. Complications will be defined as<br /><br>the presence of SIRS, sepsis, or evidence of organ failure based on<br /><br>internationally accepted biochemical and/or clinical criteria. We will<br /><br>correlate the increase of studied plasma and urinary markers for intestinal<br /><br>epithelial cell damage and inflammation with the occurence of post-operative<br /><br>morbidity and complications.<br /><br>The peak levels of studied markers will be correlated with the amount of<br /><br>hypoperfusion, measured by gastric tonometry. The release of intestinal cell<br /><br>damage and inflammation markers will be correlated with the amount of blood<br /><br>loss, duration and extension of surgery.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measurements will consist of duration of intensive care unit<br /><br>stay, postoperative onset of feeding, use of antibiotics.</p><br>