Alcohol Use and Behavior in Young Adults
- Conditions
- Alcohol Use Disorder (AUD)Therapeutic area: Psychiatry and Psychology [F] - Behavior and Behavior Mechanisms [F01]
- Registration Number
- CTIS2022-501809-13-01
- Lead Sponsor
- Karolinska Institutet
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Male
- Target Recruitment
- 220
18-24 years of age, Male, Give informed consent and comply with study procedure, High alcohol use individuals: Fulfils criteria for at least moderate AUD the past 12 months according to MINI Neuropsychiatric Interview, High alcohol use individuals: Fulfils at least 8 points on the Alcohol Use Disorder Identification Test
Fulfils criteria for any substance use disorder (except AUD for High Alcohol-group, and mild cannabis- and nicotine use disorder for both groups)., History of severe psychiatric disorder (e.g. severe depression, bipolar, antisocial personality disorder) or neuropsychiatric disorder of ADHD, autism or Tourette’s., Using intranasal medicine that could not be stopped 48 hours prior to each visit, Allergy or intolerance to preservatives in nasal spray, e.g. latex allergy., Upper-respiratory tract infection (i.e. a ‘common cold’ resulting in significant nasal congestion) at day of testing (but with the possibility of rescheduling for another time point)
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Does oxytocin (compared to placebo) for individuals with high alcohol use increase prosocial behavior?;Secondary Objective: Does oxytocin (compared to placebo) for individuals with high alcohol use increase emotion recognition and reduce alcohol craving?;Primary end point(s): Prosocial behavior using a dictator game task measured at both study visits 35-75 minutes after administration of the investigational medicinal product.
- Secondary Outcome Measures
Name Time Method Secondary end point(s):Impulsivity using a delay discounting task, emotion recognition using an emotion recognition task, social learning using an observational fear learning task, and alcohol craving using an alcohol cue-craving task measured at both visits 76-120 minutes after administration of the investigational medicinal product.