Youth Nominated Support Team

Not Applicable

Recruiting

• Conditions: Psychosis; Family Members; Suicide; Health Care Utilization
• Interventions: Behavioral: Youth-Nominated Support Teams for CHR

• Registration Number: NCT05558332
• Lead Sponsor: University of California, Irvine

Brief Summary

This study aims to adapt the current Youth-Nominated Support Team (YST) manual used to treat suicide risk for people at clinical high risk for psychosis.

Detailed Description

Psychotic disorders are characterized by high rates of suicidal ideation and behavior, and the risk for suicide appears to be greatest during the earliest stages of psychosis. A recent meta-analysis showed that the majority of youth at clinical high-risk (CHR) for psychosis experience suicidal ideation, and that approximately one in five make at least one suicide attempt. There are, however, no suicide prevention interventions specifically tailored to the needs of transition-aged youth at CHR, and no current best practice guidelines for how to respond to suicide risk in this population. The Youth-Nominated Support Team (YST) intervention has recently been shown to reduce mortality among adolescents and is potentially highly adaptable within the context of existing CHR services. YST is intended as an adjunctive treatment and is primarily delivered towards support persons rather than the youth themselves, and therefore would not interfere or overlap with the already extensive direct services provided in CHR treatment settings. The proposed project intends to adapt the YST intervention for CHR populations. Specifically, the investigators aim to: (1) adapt YST for CHR based on stakeholder input (i.e., clients, family/friends, clinicians) and to develop a new treatment manual and submit an additional IRB to cover the next two aims -- (2) to implement YST in a single CHR clinic and to revise the intervention based on input from clients, providers, and support person and (3) conduct a pilot randomized clinical trial at four SAMHSA funded CHR sites to test the efficacy of the adapted YST intervention and to identify underlying mechanisms of change. The investigators hypothesize that the revised intervention will be superior to existing practice for the reduction of suicidal ideation and behavior.

Study Timeline

• Study First Submitted: 2022-09-16
• Study First Submitted QC: 2022-09-23
• Study First Posted: 2022-09-28
• Study Start: 2025-03-12
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-04
• Last Update Posted: 2025-04-08
• Primary Completion: 2025-09
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• A person with suicidal ideation in the past 3 months or suicidal attempt in the past year
• A person who is receiving or has received treatment for psychosis risk symptoms
• Between the ages of 12-25

Exclusion Criteria

• Cannot have participated in the first 2 phases of the study (focus groups and adaption of the YST-CHR manual)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
YST-CHR Group	Youth-Nominated Support Teams for CHR	This group will recieve the new adapted YST treatment (YST-CHR). Clinicians will administer this treatment. Neither group will be blind.

Primary Outcome Measures

Name	Time	Method
Social Connectedness	3-months after intervention	Connectedness will be measured with the 5-item Thwarted Belongingness subscale of the Interpersonal Needs Questionnaire. Scores range from 15-105 and a higher score indicates lower social connectedness.
Increased Hope	3-months after intervention	Hopelessness will be measured with the 4-item Beck Hopelessness Scale (BHS). Hopelessness may be a very sensitive indicator of subsequent suicide risk, particularly among youth with psychosis. The total BHS score is a sum of item responses from 0 to 20 such that higher scores reflect higher levels of hopelessness. Scores greater than 14 identify severe hopelessness.
Treatment Engagement	3-months after intervention	This will be measured using clinic records of appointment attendance to determine number of therapy sessions attended.

Secondary Outcome Measures

Name	Time	Method
Severity and Intensity of Suicidal Ideation	baseline, 6 weeks after intervention, and 3 months after intervention	This will also be drawn from the Suicide History of Assessment for People with Psychosis-Spectrum Experiences (SHAPE). This measure is used to query about suicidal thoughts and actions and history with these experiences. It is not scored but used to get a better understanding of the participant's thoughts and feelings related to suicide.

Trial Locations

Locations (1)

The PREVENT Lab, University of California, Irvine; 🇺🇸 Irvine, California, United States