Radioprotective effect of melatonin for hyperthyroidism treatment with iodine-131

Phase 2

• Conditions: Condition 1: Hyperthyroidism. Condition 2: Radiation damages.; Disorders of thyroid gland; Exposure to ionizing radiation; E00-E07

• Registration Number: IRCT2014090419045N1
• Lead Sponsor: Babol University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

female; right-handed; blood group: O+; receiving 12 mCi iodine-131
Exclusion criteria: individuals who have genetic disorders ,cancer or chemical injuries; smokers; radiation workers; and patients undergoing chemotherapy

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Micronuclei frequency. Timepoint: Just before iodine-131 administration; and also 1 hour after that. Method of measurement: Cytokinesis blocked micronuclei assessment.

Secondary Outcome Measures

Name	Time	Method
Thyroid gland function. Timepoint: Before intervention; and 3 months after. Method of measurement: TSH, T4 and T3 level in blood samples.