Tissue Bank for Studies Related to Graft-Versus-Host Disease (GVHD)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 190
- 试验地点
- 3
- 主要终点
- Tissue bank for proteomic studies using donor and recipient blood and urine samples
研究概览
简要总结
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.
PURPOSE: This research study is collecting and storing tissue and DNA samples from patients undergoing a donor stem cell transplant.
详细描述
OBJECTIVES:
- To establish a DNA bank from donor and recipient (prior to transplant) peripheral blood for SNP studies.
- To establish a tissue bank for gene expression studies using donor and recipient (post-transplant) peripheral blood samples.
- To establish a tissue bank for proteomic studies using donor and recipient blood and urine samples.
- To establish a tissue bank for various studies using biopsy specimens.
- To establish a tissue bank for flow cytometric studies using recipient (post-transplant), and sample from stem cell product.
OUTLINE: Peripheral blood samples are collected from donors prior to stem cell mobilization and from patients prior to starting preparative regimen. Samples are studied by single nucleotide polymorphism (SNP) analysis, SNP array, proteomic analysis, gene expression, and other immunological laboratory methods. Blood, urine, and tissue samples are preserved for future studies. Extra skin biopsies and gastrointestinal biopsies are performed at diagnosis of graft-vs-host disease and preserved in a tissue bank for flow cytometric studies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Tissue bank for proteomic studies using donor and recipient blood and urine samples
时间窗: End of treatment
DNA bank from donor and recipient (prior to transplant) peripheral blood for single nucleotide polymorphism studies
时间窗: Completion of transplant
Tissue bank for gene expression studies using donor and recipient (post-transplant) peripheral blood samples
时间窗: End of treatment
Tissue bank for flow cytometric studies using recipient (post-transplant), and sample from stem cell product
时间窗: End of treatment
次要结局
未报告次要终点
研究者
Madan Jagasia, MD
Associate Professor of Medicine; Director, Outpatient Transplant Program; Section Chief, Hematology and Stem Cell Transplant;
Vanderbilt-Ingram Cancer Center