Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness

Completed

• Conditions: Lipid Overnutrition; Constitutional Thinness
• Interventions: Behavioral: Lipid overnutrition

• Registration Number: NCT01224561
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Detailed Description

This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2010-10-18
• Study First Submitted QC: 2010-10-19
• Study First Posted: 2010-10-20
• Primary Completion: 2011-01
• Study Completion: 2011-01
• Status Verified: 2011-05
• Last Update Submitted: 2011-05-04
• Last Update Posted: 2011-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 26

Inclusion Criteria

• consent form the study signed
• consent form for genetic study signed
• normal laboratory values for liver enzymes, glucose, lipid

Exclusion Criteria (common to the two groups):

• pregnant
• vegetarian
• heavy smoking
• heavy alcohol
• depressive
• taking hypolipidemic or antihypertensive drugs
• dyslipidemia

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy Volonteer	Lipid overnutrition	Women with a body mass index between 20 and 25 kg/m2
Constitutional thinness	Lipid overnutrition	Women with a a body mass index of less than 16.5 kg/m2

Primary Outcome Measures

Name	Time	Method
gene expression	After one month of lipid overnutrition	Level of genes (which regulate the lipid and energy metabolism) expression in fat and muscle tissues

Secondary Outcome Measures

Name	Time	Method
Anthropometric parameter	After one month of lipid overnutrition	Fat mass
Autonomic nervous system activity	After one month of lipid overnutrition	Heart rate variability analyses using ECG Holter monitoring
gastrointestinal hormone level	After one month of lipid overnutrition	Serum level of PYY

Trial Locations

Locations (3)

CRNH Auvergne; 🇫🇷 Clermont-Ferrand, France

CHU de Saint-Etienne; 🇫🇷 Saint-etienne, France

CRNH Rhône-Alpes; 🇫🇷 Lyon, France