Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance
- Conditions
- Insulin Resistance
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT00954109
- Lead Sponsor
- US Department of Veterans Affairs
- Brief Summary
The overall aim of the project is to determine whether or not exercise influences cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance or type 2 diabetes.
- Detailed Description
Participants will undergo a screening procedure, including telephone screening and physical examination, as well as determination of body composition and fitness. Participants will be asked to complete 5-10 days of supervised exercise training and will undergo testing to assess cardiovascular and metabolic responses to an oral glucose tolerance test, including muscle sympathetic nerve activity, blood flow, and circulating glucose and insulin concentrations at baseline and following training. In addition, day-to-day variations in blood glucose will also be monitored. The overall aim of the project is to determine whether or not acute exercise training influences postprandial metabolic, vascular or autonomic nervous system responses in individuals with insulin resistance or T2D.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
- Insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 100 mg/dL
- T2D: diagnosed by primary care physician
- BMI: less than 43 kg/m2
- Age: 30-65
- Smoking
- Insulin use (other than once daily)
- Underlying conditions that limit ability to exercise safely
- Recent weight gain or loss (>5% of body weight in 3 months)
- Physically active (>30 min aerobic exercise, 2 d/wk)
- Recent (<3 mo) changes in medication use or dose
- Uncontrolled T2D (HbA1c>10%)
- Advanced retinopathy or neuropathy
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Exercise Exercise exercise - supervised exercise (treadmill walking or cycle ergometer use)
- Primary Outcome Measures
Name Time Method Insulin Sensitivity After 5-7 Days of Exercise baseline and 24h after 5-7 days of exercise Insulin sensitivity measured during an oral glucose tolerance test measured by the Matsuda Index. Matsuda insulin sensitivity index= 10000/square root of \[(fasting glucose × fasting insulin) × (mean glucose × mean insulin during oral glucose tolerance test).
Blood Flow in Response to Oral Glucose Tolerance Tests pre and 24 hours post 5-7 days of exercise Blood flow response in the femoral artery measured by Doppler ultrasound during and oral glucose tolerance test. Data are represented as % change in blood flow during the oral glucose tolerance at 60 minutes vs. 0 minutes (prior to drinking the glucose)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Harry S. Truman Memorial VA Medical Center
🇺🇸Columbia, Missouri, United States