Physical Inactivity and Insulin Resistance in Skeletal Muscle
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Insulin Sensitivity After 5-7 Days of Exercise
研究概览
简要总结
The overall aim of the project is to determine whether or not exercise influences cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance or type 2 diabetes.
详细描述
Participants will undergo a screening procedure, including telephone screening and physical examination, as well as determination of body composition and fitness. Participants will be asked to complete 5-10 days of supervised exercise training and will undergo testing to assess cardiovascular and metabolic responses to an oral glucose tolerance test, including muscle sympathetic nerve activity, blood flow, and circulating glucose and insulin concentrations at baseline and following training. In addition, day-to-day variations in blood glucose will also be monitored. The overall aim of the project is to determine whether or not acute exercise training influences postprandial metabolic, vascular or autonomic nervous system responses in individuals with insulin resistance or T2D.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 100 mg/dL
- •T2D: diagnosed by primary care physician
- •BMI: less than 43 kg/m2
- •Age: 30-65
排除标准
- •Insulin use (other than once daily)
- •Underlying conditions that limit ability to exercise safely
- •Recent weight gain or loss (>5% of body weight in 3 months)
- •Physically active (>30 min aerobic exercise, 2 d/wk)
- •Recent (<3 mo) changes in medication use or dose
- •Uncontrolled T2D (HbA1c>10%)
- •Advanced retinopathy or neuropathy
- •Pregnancy
结局指标
主要结局
Insulin Sensitivity After 5-7 Days of Exercise
时间窗: baseline and 24h after 5-7 days of exercise
Insulin sensitivity measured during an oral glucose tolerance test measured by the Matsuda Index. Matsuda insulin sensitivity index= 10000/square root of \[(fasting glucose × fasting insulin) × (mean glucose × mean insulin during oral glucose tolerance test).
Blood Flow in Response to Oral Glucose Tolerance Tests
时间窗: pre and 24 hours post 5-7 days of exercise
Blood flow response in the femoral artery measured by Doppler ultrasound during and oral glucose tolerance test. Data are represented as % change in blood flow during the oral glucose tolerance at 60 minutes vs. 0 minutes (prior to drinking the glucose)
次要结局
未报告次要终点