Comparing efficacy of loading and non-loading colchicine in acute crystal induced arthritis

Phase 4

Recruiting

• Conditions: - Gout- CPPD- Colchicine; crytal induced arthritis; gout; CPPD; acute gout attack; gouty arthritis; colchicine

• Registration Number: TCTR20180608001
• Lead Sponsor: none

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-08
• Study Completion: 2018-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

- Patients aged 18 years or older.
- Acute CPPD or gout arthritis within 48 hours, confirmed with synovial fluid examination or diagnosed by ACR/EULAR CLASSIFIACTION CRITERIA FOR GOUT 2015.
- Never exposed to uric lowering agent, or use uric lowering agent in stable dose for at lease 30 days.
- Prescribed colchicine 0.6 mg. per day or less
- Prescribed prednisolon 5 mg. per day or lass

Exclusion Criteria

- Co-exiting other causes of arthritis.
- Patients who have contraindication to colchicine.
- Patient who received analgesic or NSAIDs before included.
- eGFR less than 30 by Cockcroft-Gault equation
- Patients who cannot estimate pain score
- Patients who have significantly severe co-mordities.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain score reduction after 24 hours 24 hours visual analog scale

Secondary Outcome Measures

Name	Time	Method
Pain score reduction at 6, 12, and 48 hours 6, 12, and 48 hours visual analog scale,proportion of patients who have at least 50% pain score reduction 24 and 48 hours Pain score reduction after 24 hours,Pain score reduction after 24 hours in patient with eGFR more than 60 and less than 60 24 hours Pain score reduction after 24 hours,sign of inflammation 24 hours scaling score,side effects 24,48 hours record,Patients satsfaction 48 hours visual analog scale