Second Trimester Maternal Serum Homocysteine Level & Uterine Artery Doppler for Prediction of Preeclampsia , Intra-Uterine Growth Retardation (IUGR) & Other Obstetric Complications
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 主要终点
- Number of pregnants who developed preeclampsia, those who developed IUGR alone and those who developed other obstetric complications as preterm labour and placental abruption
研究概览
简要总结
Second trimester homocysteine & uterine artery doppler will be assessed& the cases will be followed up till delivery for development of preeclampsia, IUGR(intra-uterine growth retardation) & other obstetric complications.
详细描述
Spontaneous pregnancies with no risk factors will be included. Fasting plasma total homocysteine level samples will be collected between 15th & 19th weeks.
Uterine artery doppler between 18th & 22nd weeks.
Method 1: Screen positive cases will be considered if homocysteine level above 6.3umol/l
Method 2: Screen positive cases will be considered if they had bilateral notches and a mean resistivity index (RI) above 0.55, or unilateral notches and a mean RI above 0.65, or absence of notches and a mean RI above 0.7.
Method 3: Screen positive cases will be considered if they had bilateral notches and a mean RI above 0.55, or unilateral notches and a mean RI above 0.65, or absence of notches and a mean RI above 0.7 combined with homocysteine cut off value of 6.3umol / l.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •spontaneous pregnancies with no risk factors
排除标准
- •multiple pregnancies
- •non intact renal function
- •hypertension
- •folic acid supplements
- •antifolate drugs
结局指标
主要结局
Number of pregnants who developed preeclampsia, those who developed IUGR alone and those who developed other obstetric complications as preterm labour and placental abruption
时间窗: 4 months
次要结局
未报告次要终点
研究者
suzy abdelaziz Abdelhamid
lecturer of Obgyn
Kasr El Aini Hospital