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临床试验/NCT03615989
NCT03615989终止不适用

Does Milk Augment the Acute Effect of Exercise on Bone Turnover and Inflammation

York University2 个研究点 分布在 1 个国家目标入组 13 人开始时间: 2018年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
13
试验地点
2
主要终点
Acute Bone Cell Activity

研究概览

简要总结

This study analyzes whether dairy supplementation positively impacts loading exercise-induced bone cell activity and inflammation in healthy young females.

详细描述

Introduction: Two million individuals at a cost of around 2.3 billion dollars a year in Canada suffer from osteoporosis. Research that emphasizes the treatment of this disease is important, but so is research that focuses on prevention; reducing bone loss and/or increasing bone mass when young. In addition, inflammation is an issue as it strongly relates to chronic disease. Countermeasures to improve bone health and inflammation, such as nutrition and exercise, should be explored and implemented. The proposed research combines both nutrition and exercise along with the assessment of bone turnover markers and inflammation in healthy young females, and aims to determine whether dairy versus a carbohydrate-based beverage positively impacts acute bone turnover and the inflammatory response following a bout of resistance and plyometric exercise.

Design: Randomized controlled crossover trial.

Participants: 13 healthy university aged females.

Methods: Participants were asked to complete 2 different acute exercise and nutritional supplement trials. Each trial will be assigned in random order. The two trials were: 1) exercise+carbohydrate (CHO), and 2) exercise+milk (Milk). The whole study, per participant, took a maximum of 8-12 weeks to complete as each supplement trial was separated by ~4 weeks. Each treatment is outlined below.

******DUE TO COVID-19, we removed the treatment trial which involved milk+creatine supplementation. Despite randomization, and before the trial was closed, only 11 participants completed this trial********

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
Single (Outcomes Assessor)

盲法说明

Those completing the analyses were masked to the treatments.

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Female between the ages of 18 and 30 years
  • Normal BMI (18.5-24.9) kg/m2
  • Low to moderately physically active (0-2 times/week)
  • No allergy to dairy protein or lactose intolerance
  • On no medication related to a chronic condition
  • On birth control (or not but with regular mensural cycle)

排除标准

  • 未提供

结局指标

主要结局

Acute Bone Cell Activity

时间窗: 48 hours post exercise

Bone markers (OPG, RANKL, OC) measured in serum/plasma.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Andrea Josse

Assistant Professor

York University

研究点 (2)

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