Gender differences in P-gp transporter function measured with [18F]MC225 PET imaging

Phase 1

• Conditions: Gender, healthy volunteers; Therapeutic area: Body processes [G] - Biological Phenomena [G16]

• Registration Number: EUCTR2022-003664-25-NL
• Lead Sponsor: niversity Medical Center Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-04-28
• Last Update Posted: 8 January 2024

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

- Healthy volunteers
- Age: 50-80 years
- MMSE: 28-30
- No history of any neuropsychiatric disorders that might affect the P-gp function or blood-brain barrier integrity
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range 0
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 5

Exclusion Criteria

- Use of medication with known P-gp affinity
- History of neuropsychiatric disorders affecting the P-gp function or blood-brain barrier integrity

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified