Differences in Immunologic Response to Cryoablation Versus Radiofrequency Ablation in the Treatment of Renal Cell Carcinoma

Terminated

• Conditions: Immune Response to 3 Approaches

• Registration Number: NCT03409224
• Lead Sponsor: University of California, Irvine

Brief Summary

The purpose of this study is to compare changes in the body's self-defense (immune response) after two different treatments for small kidney tumors: 1) Cryoablation (freezing) therapy in which the tumor and a margin of normal kidney tissue are frozen and thawed twice with a needle probe and 2) radiofrequency ablation (RFA) in which radiofrequency energy delivered through a needle probe is used to heat tissue and thereby destroy a tumor.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-01
• Study First Submitted: 2016-12-12
• Study First Submitted QC: 2018-01-23
• Study First Posted: 2018-01-24
• Primary Completion: 2019-04
• Study Completion: 2019-04
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-15
• Last Update Posted: 2021-04-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 53

Inclusion Criteria

• You are eligible to participate in this study if you are an adult (older than 18 years)
• Diagnosed with renal cell cancer 1-3 centimeters in size on the CT scan.

Exclusion Criteria

• You are not eligible to participate in this study if you are immune compromised (chemotherapy,corticosteroid use, HIV [as documented in your medical record], etc.)
• Have an autoimmune disorders (Rheumatoid arthritis, Crohn's disease, etc)
• Have a tumor larger than 4 cm
• Are pregnant.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Immune Response to Cryoablation, RFA and Laparoscopic Partial Nephrectomy	4 years	The number of leukocytes found in the tissues cryoablation, radiofrequency ablation, or laparoscopic partial nephrectomy (control)