ltrasound-guided Prolotherapy, Oxygen-ozone and corticosteroid injection for treatment of knee osteoarthritis
Phase 3
- Conditions
- Osteoarthritis of knee.Osteoarthritis of knee
- Registration Number
- IRCT20151017024572N23
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
Patients with mild to moderate osteoarthritis of the knee (Kellgren Lawrence grade I, II and III)
Knee pain for at least six months
Exclusion Criteria
History of knee surgery or fracture
History of knee meniscus or ligaments tear (ACL/PCL/MCL/LCL)
Pregnancy
History of allergic reaction to Corticosteroid, Dextrose or Ozone
Infection at the injection site
Uncontrolled diabetes
History of systemic inflammatory or connective tissue disease
History of knee injections in the last three months
History of gout
Secondary knee osteoarthritis
Contraindications of ozone therapy (deficiency G6PD, uncontrolled hyperthyroidism, leukemia)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual Analog Scale (VAS). Timepoint: Before intervention, 1 and 8 weeks after intervention. Method of measurement: Visual Analogue Scale Questionnaire.
- Secondary Outcome Measures
Name Time Method Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Timepoint: Before intervention and 1, 8 weeks after intervention. Method of measurement: Questionnaire.