Effects of routine infant vaccination with the 7-valent pneumococcal conjugate vaccine on nasopharygeal colonization with streptococcus pneumoniae in children and parents in the Netherlands.
Completed
- Conditions
- Prevenar vaccination, Immune system, pneumococcal carriage.
- Registration Number
- NL-OMON23549
- Lead Sponsor
- ederlands Vaccin Instituut (NVI)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 660
Inclusion Criteria
1. The children have to be of normal health (same health criteria apply as used in well-baby clinics when a child receives a vaccination, e.g. also children with small increases in temperature or cold are seen as children with normal health);
2. They have to be willing and able to participate in the trial according to procedure;
Exclusion Criteria
1. Previous vaccinations with Prevenar® using a schedule that differs from the Dutch 3+1 schedule;
2. Previous vaccinations with other pneumoccocal vaccines;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The percentage of the (the seven) vaccine and non-vaccines pneumococcal serotypes found in the NP swabs from children at 11 and 24 months of age and parents of the 24-month-old children.
- Secondary Outcome Measures
Name Time Method The percentage of children and parents positive for S.aureus, H. influenzae and M. catarrhalis.