Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

Completed

• Conditions: Chronic Periodontitis
• Interventions: Procedure: nonsurgical periodontal treatment

• Registration Number: NCT03644901
• Lead Sponsor: Damascus University

Brief Summary

The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

Detailed Description

To the best of our knowledge, this is the first (research) randomized clinical trial that assesses how patient respond to the nonsurgical periodontal treatment based on their blood group phenotype.

Study Timeline

• Study Start: 2018-01-15
• Study First Submitted: 2018-08-02
• Study First Submitted QC: 2018-08-22
• Study First Posted: 2018-08-23
• Primary Completion: 2018-10-01
• Status Verified: 2019-03
• Study Completion: 2019-03-10
• Last Update Submitted: 2019-03-12
• Last Update Posted: 2019-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• systematically healthy.
• have at least 20 teeth excluding the third molars.
• had not received any periodontal treatment or antibiotic therapy for dental or medical reason 6 month prior to the study.
• diagnosed with generalized chronic periodontitis (>30% of the sites have probing depth ≥4), and a minimum of six teeth with probing depth of 5-6 mm.

Exclusion Criteria

• smokers and alcoholics.
• pregnancy.
• history of a systematic disease such as diabetes, leukemia, epilepsy.
• participants who are unable to perform routine oral hygiene.
• use of orthodontic appliances.
• participants who are unable to perform routine oral hygiene.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients whose blood type is A	nonsurgical periodontal treatment	Applying nonsurgical periodontal treatment (scaling and root planning).
Patients whose blood type is O	nonsurgical periodontal treatment	Applying nonsurgical periodontal treatment (scaling and root planning).
Patients whose blood type is B	nonsurgical periodontal treatment	Applying nonsurgical periodontal treatment (scaling and root planning).
Patients whose blood type is AB	nonsurgical periodontal treatment	Applying nonsurgical periodontal treatment (scaling and root planning).

Primary Outcome Measures

Name	Time	Method
Change in relative attachment level.	measures will be taken at baseline and after two months from treatment.	the relative attachment level measures the length form the base of the periodontal pocket to a stent

Secondary Outcome Measures

Name	Time	Method
Change in plaque Index	index will be taken at baseline and after two months from treatment.	it is used to designate the level of plaque accumulation.
Change in periodontal probing depth.	measures will be taken at baseline and after two months from treatment.	the distance between the gingival margin to the base of the periodontal pocket.
Change in gingival index	index will be taken at baseline and after two months from treatment.	it is used to designate the level of the gingival inflammation.

Trial Locations

Locations (1)

Department of Periodontics; 🇸🇾 Damascus, Syrian Arab Republic