Study of the Relationship Between Blood Groups,RH and Skeletal Malocclusion : a Cross Sectional Study

• Conditions: Class II Malocclusion; Class III Malocclusion
• Interventions: Diagnostic Test: blood type test

• Registration Number: NCT03085082
• Lead Sponsor: Cairo University

Brief Summary

the study is searching if there is a relationship between the blood groups and RH and the skeletal malocclusion using the skeletal class I as a control group

Detailed Description

The study will be conducted on the patients seeking medical care in the orthodontic department Cairo University, for six months all patients with class II and class III malocclusion will be recruited based on Wits appraisal measured from the cephalometric X-ray taken routinely during orthodontic examination. Then a group of class I arch length discrepancy patients will be used as control. A blood sample will be withdrawn and taken to the Cairo university laboratory to analyze the blood group and RH .a statistical analysis will be performed to detect a relationship between skeletal malocclusion and the blood groups as compared to the control

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2017-03
• Study First Submitted: 2017-03-15
• Study First Submitted QC: 2017-03-15
• Last Update Submitted: 2017-03-20
• Study First Posted: 2017-03-21
• Last Update Posted: 2017-03-22
• Study Start: 2017-04-01
• Primary Completion: 2017-09-01
• Study Completion: 2017-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

skeletal class I,II and III patients non syndromic patients above the age of 18 no previous surgical intervention for correction of skeletal malocclusion

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Exclusion Criteria

• syndromic patients
• cleft patients
• patients with previous surgery to correct skeletal malocclusion

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
skeletal class I patients	blood type test	patients with Wits appraisal between -3 and +3 that is measured from a cephalometric x ray obtained during diagnosis of arch length discrepancy. this group will serve as control and obtained after recruitment of the other 2 groups in 1 to 1 fashion
skeletal class II subjects	blood type test	patients with wits appraisal more than 3 mm measured on a cephalometric x ray obtained during diagnosis
skeletal class III subjects	blood type test	patients with wits appraisal less than -3 mm measured on a cephalometric x ray obtained during diagnosis

Primary Outcome Measures

Name	Time	Method
relationship between blood group and skeletal malocclusion	the recruitment will be for six months	If skeletal malocclusion subjects were found to have a high percentage of a certain blood type or RH when compared to the control group it will be reported that there is a relationship between blood group and skeletal malocclusion. If percentages of blood groups are approximately the same in the malocclusion subjects and the control then the investigator will report that there is no relationship between blood groups and skeletal malocclusion