Trigeminal sensitivity and hormonal fluctuations during the onset of migraine; A biochemical and neurophysiologic study in male migraineurs - Biological fluctuations in the onset of migraine

eurologie0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•Migraine patients
•Inclusion criteria are: i) males; ii) migraine with/ without aura according to the IHS criteria;
•ii) baseline attack frequency of 1 to 3 attacks per month; iii) moderate or severe headache
•during attacks; iv) age >18 years.;Healthy controls
•Healthy volunteers will be age and gender matched.

•Migraineurs:
•Exclusion criteria are: i) more than 10 days of headache
•per month; ii) inability to differentiate between migraine and other forms of headache; iii)
•suffering from only migraine auras/ migraine sans migraine; iv) current use of medication
•influencing reproductive hormone levels; v) use of prophylactic anti-migraine medication; vi)
•Body Mass Index (BMI) under 20 or above 28; or vii) current smoking (nicotine is known to
•increase CGRP release96); viii) frequent consumption of spicy foods; ix) severe arterial
•hypertension97; x) intake of high-fat foods directly before measurements (as is suggested to
•influence plasma CGRP levels98;99).;Healthy controls
•Exclusion criteria are i) personal or
•first-degree-relative history of migraine or other primary headache syndrome, except
•infrequent episodic tension type headache; ii) headache on >2 days per month; iii) BMI <20
•or >28; iv) current use of medication influencing reproductive hormone levels; v) current
•smoking96; vi) severe arterial hypertension97; vii) intake of high-fat foods directly before
•measurements (as is suggested to influence plasma CGRP levels98;99); viii) frequent consumption of spicy foods

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