Investigating the anti-headache effects of metoclopramide and acetaminophen in comparison with metoclopramide and placebo
Phase 2
Recruiting
- Conditions
- Acute migraine headache.Other headache syndromes
- Registration Number
- IRCT20151123025202N37
- Lead Sponsor
- Hamedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 88
Inclusion Criteria
The presence of migraine criteria according to the classification of the International Headache Society
Headache pattern consistent with migraine and previous attack
Exclusion Criteria
History of allergy to metoclopramide or acetaminophen
History of liver, renal and heart failure, malignancy
Pregnancy and breastfeeding
History of gastrointestinal obstruction or gastrointestinal bleeding or clinical suspicion of either
Trauma, seizure or abnormal neurological examination
Smoking or drug use
High systolic and diastolic blood pressure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Headache Severity. Timepoint: Before treatment, 15 minutes and 30 minutes after treatment. Method of measurement: Visual Analogue Scale (VAS).
- Secondary Outcome Measures
Name Time Method eed for additional analgesic. Timepoint: 60 minutes after treatment onset. Method of measurement: Extracting on patient's medical record.;Complications, nausea, vomiting, blurred vision, drowsiness and restlessness. Timepoint: Within an hour after treatment. Method of measurement: by asking the patients.