Effect of hypertonic saline on fluid requirement during major abdominal surgery.
- Conditions
- Other Procedures,
- Registration Number
- CTRI/2019/09/021032
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
This prospective randomised control trial will seek to evaluate whether 3% hypertonic saline will reduce intra operative maintenance fluid requirement in patients undergoing major abdominal surgeries in comparison with normal saline. The study will comprise of 100 patients who will be divided into two groups;group 1 will receive 3% hypertonic saline via wide bore cannula at the rate of 1ml/kg/hr and group 2 will receive normal saline at the rate of 1ml/kg/hr. Both the groups will receive maintenance fluid to maintain a target of MAP>75mmHg, urine output of 0.5-1ml/kg/hr and CVP >8-10mmHg(wherever monitored). Primary outcome will be difference in intra operative maintenance fluid requirement.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
- Patients of ASA1 and ASA2 2.
- Surgeries lasting more than 2 hours 3.
- Expected hospital stay of more than 3 days.
- Patients refusal to give consent 2.
- Inoperability 3.
- Emergency 4.
- Disturbances in serum sodium levels 5.
- Baseline elevated serum creatinine 6.
- Laproscopy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in intraoperative maintenance fluid requirements Intraoperative
- Secondary Outcome Measures
Name Time Method 1.Difference in 24hr fluid requirement 2. Need of vasopressors in 24hrs
Trial Locations
- Locations (1)
All India Institute of Medical Sciences
🇮🇳Khordha, ORISSA, India
All India Institute of Medical Sciences🇮🇳Khordha, ORISSA, IndiaDr Shri Hari Priya BeheraPrincipal investigator7681826136priya.bhr@gmail.com