Pragmatic Investigation of Volume Targeted Ventilation-1 (PIVOT-1)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Failure
- Sponsor
- Wake Forest University Health Sciences
- Enrollment
- 139
- Locations
- 1
- Primary Endpoint
- Percentage of patients receiving Assist Volume Control
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This proposal will test the feasibility of implementing an assist volume control ventilation protocol in patients receiving mechanical ventilation in the medical intensive care unit. The trial will consist of a before-and-after trial design of block assignment to either adaptive pressure control (baseline) or assist volume control .
This is a feasibility study looking at the management of patients in the ventilator.
Detailed Description
Over the course of 6 weeks, a before-and-after trial design of adaptive pressure control and assist volume control will be conducted. Pre-trial planning phase: study protocols will be reviewed with key stakeholders (respiratory therapy providers and medical teams) Weeks 1-2: data will be collected on our current adaptive pressure control ventilator protocol. Week 3: The investigators will implement an assist volume control protocol. . Patients already on mechanical ventilation will be converted to assist volume control; however, these patients will not be included in the primary analysis.In accordance with the Consolidated Framework For Implementation Research (CFIR) approach, after 1 week of assist volume control the investigators will engage in quantitative and qualitative feedback with care providers to identify facilitators and barriers of assist volume control implementation. Week 4-6: If the investigators identify substantial barriers, the investigators will pause and alter the protocol. If not, the investigators will continue assist volume control for an additional 2 weeks.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute Respiratory Failure requiring mechanical ventilation medical intensive care unit admission
Exclusion Criteria
- •chronic mechanical ventilation clinician use of non-volume-targeted ventilation as initial mode
Outcomes
Primary Outcomes
Percentage of patients receiving Assist Volume Control
Time Frame: 1 hour
The primary outcome for the PIVOT-1 pilot is feasibility of Assist Volume Control implementation. We define feasibility in this study as 80% of patients receiving Assist Volume Control within 1 hour of initiation of intensive care unit mechanical ventilation
Secondary Outcomes
- exhaled tidal volume(2 weeks)
- intensive care length of stay(28 days)
- assist volume control duration(24 hours)
- Number of ventilator free days(28 days)
- Percentage of mode crossover(2 weeks)