Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in Multiple Sclerosis

Not Applicable

Active, not recruiting

• Conditions: Multiple Sclerosis
• Interventions: Other: Diffusion-weighted magnetic resonance imaging

• Registration Number: NCT05391906
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI). In this study, the investigators evaluate the use of IVIM in patients with Multiple Sclerosis.

Detailed Description

Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI), it is achieved through an MRI acquisition with multiple small b value to extract perfusion data. It has been shown to be a promising technique in evaluation of many brain conditions. This study seeks to assess intravoxel incoherent motion (IVIM) parameters in characterizing plaques and specific tissues in multiple sclerosis.

Study Timeline

• Study First Submitted: 2022-05-03
• Study First Submitted QC: 2022-05-22
• Study First Posted: 2022-05-26
• Study Start: 2023-01-30
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-06
• Last Update Posted: 2024-02-07
• Primary Completion: 2026-12-20
• Study Completion: 2026-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Patients who are 18 years or older.
2. Relapsing-remitting MS diagnosed as per Macdonald criteria

Read More

Exclusion Criteria

1. Contraindication to MRI. For example, metal implantation in the body, claustrophobia and pregnancy.
2. Patients who are unable to tolerate the scans without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intravoxel Incoherent Motion(IVIM) MRI	Diffusion-weighted magnetic resonance imaging	Intravoxel incoherent motion (IVIM) is based on diffusion-weighted imaging (DWI)

Primary Outcome Measures

Name	Time	Method
IVIM parameters (including ADC,D,D*,f) in Multiple Sclerosis brain regions.	Up to 2 months	Primary Outcome Measure: 1. IVIM parameters (including ADC,D,D\*,f) in Multiple Sclerosis brain regions. The parameters are calculated based on a IVIM model bi-exponential model represented by: S(b)/S(0)=f ×exp(-bD\*)+ (1-f)×exp(-bD), and the mono-exponential model for ADC calculation as represented by: S(b)/S(0)=exp(-bADC), where S(b) and S (0) are the MRI signal intensities at a given b value and b = 0, respectively.; ADC: apparent diffusion coefficient. ADC is expressed in units of mm2/s.; f: the perfusion or (micro) vascular volume fraction which depends on capillary geometry and blood velocity. f is expressed in units of mm2/s.; D\*: pseudo diffusion coefficient that resembles the perfusion related incoherent microcirculation. D\* is expressed in units of mm2/s.; D: pure diffusion coefficient which is related to pure molecular diffusion. D is expressed in units of mm2/s.

Trial Locations

Locations (1)

CUHK; 🇭🇰 Hong Kong, Hong Kong