The effect of fruit constituents on gut health in healthy adult volunteers
Not Applicable
Completed
- Conditions
- gut healthproblems with gut healthDiet and Nutrition - Other diet and nutrition disordersOral and Gastrointestinal - Normal oral and gastrointestinal development and function
- Registration Number
- ACTRN12609000907246
- Lead Sponsor
- ew Zealand Institute for Plant & Food Research Limited
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Body mass index between 18 and 35kg/m2
Exclusion Criteria
They must not have a history of drug or alcohol abuse, be pregnant or breastfeeding, have any gut-related problems (except irritable bowel syndrome), diabetes mellitus, vascular disease, a mental illness, hepatitis, a compromised immune status and they must not have or have had cancer. They must not have anaemia, malnutrition from malabsorption, regularly use anti-inflammatory drugs, consume vitamin or mineral supplements, take fermented milk drinks such as Yakult or take fibre supplements such as Metamucil. They also must not be undertaking extreme exercise or suffer from exercise-related diarrhoea.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method effect on measures of gut health including quantification of various groups of bacteria in faeces[0 and Four weeks];effect on short chain fatty analysis in faeces[0 and four weeks];effect on faecal transit time in faeces using capsule marker[0 and four weeks];effect on faecal nitrogenous end points[0 and 4 weeks]
- Secondary Outcome Measures
Name Time Method effect on gut regularity as measured by a questionnaire[Daily for four weeks following randomisation];effect on bowel motions as measured by a questionnaire[daily for four weeks following randomisation];effect on general well being as measured by a questionnaire[daily for four weeks following randomisation]