Effect of polyphenol rich extract of licorice on improving symptoms of Parkinson disease
Phase 3
Recruiting
- Conditions
- Parkinson disease.Parkinson's disease
- Registration Number
- IRCT20120305009204N3
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age between 30 to 80 years
idiopathic parkinson disease (PD)
initiation of PD symptoms in recent 6 years
The modified Hoehn and Yahr Scale: staging = 3
no treatment changes within 4 weeks before starting the intervention
Exclusion Criteria
Consumption of warfarin; selective serotonin reuptake inhibitors (SSRI), Monoamine oxidase inhibitors (MAOIs), or diuretic
History of stroke; myocardial infarction; heart failure; renal failure or cardiac arrhythmia
Uncontrolled hypertension and hypokalemia
pregnant and lactating women
Liver diseases
Diabetes
complication of treatment including urticaria, pruritis, nasea and vomiting and vertigo
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method nified Parkinson’s Disease Rating Scale (UPDRS). Timepoint: First visit and every 6-8 weeks up to 6 months after intervention began. Method of measurement: Examination by the neurologist physician and Rating the diseases scale based on the Unified Parkinson's Disease Rating Scale (UPDRS).
- Secondary Outcome Measures
Name Time Method Patients electrolytes level. Timepoint: At the beginning of the study and every 6-8 weeks for six months after the intervention began. Method of measurement: Serologic tests.;Patients blood pressure. Timepoint: At the beginning of the study and every 6-8 weeks for six months after the intervention began. Method of measurement: Measurement by the physician with a blood pressure monitor.