Effects of high intensity interval training on skeletal muscle metabolism and oxygenation in patients with chronic heart failure.

Recruiting

Conditions: Chronic heart failure, High intensity training, Skeletal muscle metabolism

Registration Number: NL-OMON22308

Lead Sponsor: Maxima Medisch Centrum Veldhoven

Brief Summary: Kemps HMC, Prompers JJ, Wessels B, de Vries WR, Zonderland ML, Thijssen EJM, et al. Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization. Clin Sci (Lond) 2010 Feb;118:203-10.

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

1. Written informed consent;

2. Stable systolic heart failure secondary to ischemic or dilated cardiomyopathy New York Heart Association (NYHA) class II or III (without change in class or medication < 3 months prior to inclusion);

Exclusion Criteria

1. Pacemaker / implantable cardioverter defibrillator (ICD) or other contra indication for magnetic resonance imaging;

2. Claustrophobia;

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in skeletal muscle metabolic recovery after submaximal exercise (leg extension in the supine position) assessed by 31P MR spectroscopy measurements in M. vastus lateralis after 3 months of physical training (rate of post-exercise phosphocreatine increase, expressed as tau-PCr). Changes in skeletal muscle re-oxygenation assessed simultaneously at the same location by Near Infrared Spectroscopy (rate of post-exercise decrease in deoxygenated hemoglobin, expressed as MRT-HHb).

Secondary Outcome Measures

Name	Time	Method
Changes in maximal exercise capacity (by changes in peak Vo2), left ventricular function (left ventricular ejection fraction and end systolic volume) and Quality of life (Minnesota living with heart failure questionnaire) after 3 months of physical training.