Perioperative maintenance of global tissue perfusion and volemic state in abdominal surgery: Nexfin cardiac output and pulse pressure variation versus arterial blood pressure-guided therapy
Completed
- Conditions
- Abdominal surgerybowel surgery10017998
- Registration Number
- NL-OMON37876
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 275
Inclusion Criteria
Patients undergoing elective abdominal surgery
Age 18-85 years
Exptected duration of surgery > 90 minutes
Informed consent
Exclusion Criteria
Preexisting cardiac arrhythmias
Emergency operation
ICU patients
Body mass index below 20 kg/m2 and above 40 kg/m2.
Patients without an invasive arterial line
Decompensatio cordis
Aortic valve disease
Ejection fraction < 0.3
Aortic valve stenosis: surface < 1.2 cm2
Pulmonary arterial pressure > 30 mm Hg, TAPSE < 18 mm
Incapacitated patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study endpoints: The primary endpoint is defined as postoperative<br /><br>morbidity based on the incidence of a number of predefined complications until<br /><br>30 days after surgery. These parameters include, among others, reoperation,<br /><br>infections, rehabilitation and restoration of gastrointestinal function. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints include hospital length of stay and microcirculatory<br /><br>perfusion.</p><br>