Pulsatile II study.
Completed
- Conditions
- coronary artery bypass graft surgery, pulsatile cardiopulmonary bypass, microcirculatory perfusion, endothelial function, platelet aggregation, fibrinolysis
- Registration Number
- NL-OMON21204
- Lead Sponsor
- VU Medisch Centrum; Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
1. Patients undergoing coronary artery bypass surgery (CABG);
2. Age 40-85 years;
Exclusion Criteria
1. Re-operations and emergency operations;
2. Patients with insulin-dependent diabetes mellitus;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in microcirculatory perfusion during surgery, sublingual erythrocyte velocity, capillary diameter and capillary density.
- Secondary Outcome Measures
Name Time Method 1. Platelet aggregation;<br /><br>2. Fibrin formation/degradation;<br /><br>3. Red blood cell deformability;<br /><br>4. Endothelial barrier function;<br /><br>5. Endothelial biomarker expression.