nraveling the Genetic Background of Colorectal Cancer in Adolescents and Young Adults.
Completed
- Conditions
- colon cancerlarge bowel cancer100276641001799010017991
- Registration Number
- NL-OMON40790
- Lead Sponsor
- Radboudumc
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 85
Inclusion Criteria
15 individuals diagnosed with CRC <=25 years of age and
• a mismatch repair-proficient tumor
• polyposis syndromes excluded if polyps are present;and their parents. ;In addition we will anonymously include tumor DNA of 40 patients with CRC diagnosed <=25 years of age.
Exclusion Criteria
A known genetic defect in the family for a cancer unrelated condition, of which the child might be a carrier but about which the child/parents do not want to be informed.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Understanding the molecular etiology and pathogenesis of CRC in AYAs is<br /><br>expected to yield novel genetic risk factors. that will facilitate clinical<br /><br>decision making, including early tumor detection, in AYAs with CRC and their<br /><br>siblings at risk.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Identification of novel genetic risk factors voor CRC will facilitate clinical<br /><br>decision making, including early tumor detection in AYAs with CRC and their<br /><br>siblings at risk.</p><br>