Aquagenic Wrinkling Prediction

Not yet recruiting

• Conditions: Aquagenic Wrinkling of Palms; Carrier State

• Registration Number: NCT06831110
• Lead Sponsor: University of Iowa

Brief Summary

The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.

Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-05
• Study First Submitted QC: 2025-02-13
• Last Update Submitted: 2025-02-13
• Study First Posted: 2025-02-17
• Last Update Posted: 2025-02-17
• Study Start: 2025-03
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• Interested in participating in other CF Carrier-related research studies.

Exclusion Criteria

• CF patient status
• Unable to speak English
• Unable to provide written informed consent
• Prisoner status
• An open wound on either hand
• A tattoo on either hand
• Missing any portion of either hand
• Diagnosis of Diabetes
• Diagnosis of Hyperhidrosis
• Diagnosis of Raynaud's Disease
• Diagnosis of Atopic Dermatitis
• Regularly taking ACE inhibitors or angiotensin receptor blockers

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Human Observation of Wrinkling	Up to 20 minutes	Photos of hands will be scored on a scale of 0 (no wrinkling) to 4 (severe wrinkling) at each minute by human observers.
Machine-Learning Observation of Wrinkling	Up to 20 minutes	Photos of hands will be scored by a machine-learning algorithm at each minute.