NCT06404723尚未招募不适用
The Predictive and Prognostic Values of the Fibrinogen to Albumin Ratio and C-reactive Protien to Albumin Ratio in Systemic Lupus Erythematosus Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 150
- 主要终点
- Fibrinogen/Albumin ratio, C-reactive protein /Albumin ratio
研究概览
简要总结
The aim of the study was to study the predictive value of FAR and CAR in order to provide a new predictive biomarkers for the disease activity and prognosis.
详细描述
A total of 150 participants were included in a Case-Control study:
- Healthy control group: this group contains 50 healthy individual.
- Lupus simplex (mild and moderate disease activity) group: this group contains 50 patients with a systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score less than 15.
- Severe disease activity group: this group contains 50 patients with a systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) score ≥ 15.
Setting:
This study will be conducted to All patients will enter to The Rheumatology Department, Sohag University Hospital for one year.
Inclusion criteria:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed as SLE according to SLICC 2012 or ACE/EULAR 2017 classification criteria with
- •≥18 years of age.
- •Complete clinical and laboratory investigations.
- •No concomitant infection, systemic or other autoimmune diseases.
排除标准
- •Patients were excluded from the study if they had any of the following:
- •<18 years of age,
- •Incomplete clinical data and laboratory indicators.
- •End-stage kidney disease (defned as requiring dialysis, kidney transplantation, or estimated glomerular fltration rate (eGFR)<15 mL/min/1.73 m2
- •Patients with:
- •Acute infectious diseases, HIV infection carriers,
- •Concomitant systemic diseases such as chronic obstructive lung disease, coronary artery disease, cancer, thyroid function disorder, hematological disorders, acute or chronic liver and renal diseases.
- •Patients with had other autoimmune diseases, such as rheumatoid arthritis, systemic sclerosis, or primary Sjogren's syndrome.
结局指标
主要结局
Fibrinogen/Albumin ratio, C-reactive protein /Albumin ratio
时间窗: 1-6-2024 to 1-6-2025
detect if the results approve their use as a predictive and prognostic tools for SLE
次要结局
未报告次要终点
研究者
Manar Gamal Mohamed
Specialist of Physical Medicine, Rheumatology and Rehabilitation at Medical Admintsration at Sohag University
Sohag University
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