Effect of Nicardipine bolus before infusion on blood pressure in acute spontaneous intracerebral hemorrhage

Phase 4

Completed

• Conditions: acute phase; SBP; BP; Nicardipine; bolus; infusion; intravenous; compare; versus; Spontaneous intracerebral hemorrhage patients with systolic blood pressure greater than 180 mmHg without intraventricular hemorrhage or subarachnoid hemorrhagehematoma volume less than 60 ml.onset less than 6 hours Effect of a bolus dose of Nicardipine on blood pressure prior to continuous drip

• Registration Number: TCTR20220622004
• Lead Sponsor: avamindradhiraj University

Brief Summary

There were no significant differences in baseline SBP between the two groups, but the bolus group achieved the target SBP of 180 mmHg more rapidly. No patients in either group experienced neurological deterioration during the first hour of treatment, and the infusion dosages of Nicardipine at 1 hour were not statistically significantly different in both groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-22
• Study Completion: 2023-07-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

1. Spontaneous intracerebral hemorrhage
2. 18-year-old or more
3. Systolic blood pressure 180 mmHg or more
4. GCS more than 5

Exclusion Criteria

1. pregnancy
2. intraventricular hemorrhage, subarachnoid hemorrhage
3. Hematoma volume greater than 60 milliliters
4. onset more than 6 hours
5. refer in
6. allergic to Nicardipine
7. unobtainable a consent form

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure every 5 minutes within 1st hour mmHg, automated blood pressure cuff

Secondary Outcome Measures

Name	Time	Method
eurological deterioration 1 hour since presentation Glasgow coma score; GCS,Nicardipine infusion rate 1 hour since nicardipine infusion initiation mg/h