A study to evaluate the effect of an ayurvedic treatment protocol prior to in vitro fertilization in women with diminished ovarian reserve and understanding the molecular mechanisms involved.
Phase 3
- Conditions
- Health Condition 1: N979- Female infertility, unspecified
- Registration Number
- CTRI/2023/11/059872
- Lead Sponsor
- Amrita School of Ayurveda
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1)Participant willing and able to give informed consent for participation in the trial.
2)Diagnosed with Diminished ovarian reserve (serum AMH <1.1 ng/ml, AFC < 7 follicles)
3)Poor ovarian response in the prior IVF cycle
Exclusion Criteria
1)Diagnosed of genetic disorders
2)Undergoing treatment for malignancy
3)History of oophorectomy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Improvement in Ultrasonography count of ovarian antral follicles, Antral follicle count (AFC) - on Day 2/3 of the menstrual cycle <br/ ><br>2)Improvement in serum anti-Mullerian hormone (AMH) – Day 2/3 of the Menstrual CycleTimepoint: Assessment before treatment (BT) will be done during recruitment and post assessment after treatment (AT) will be done after two months of Ayurvedic treatment.
- Secondary Outcome Measures
Name Time Method Multi omics analysis of follicular fluid - (Treatment group - 10; after two months of Ayurveda treatment and Control group - 10).Timepoint: On the day of oocyte retrieval during In Vitro fertilization.