REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness

Completed

• Conditions: Consciousness Disorder; Coma; Brain Injuries, Traumatic

• Registration Number: NCT03504709
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-3-20
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

Patients:<br><br>Inclusion Criteria:<br><br> - Traumatic Brain Injury<br><br> - Glasgow Coma Scale score of 3-8 within 24 hours, unconfounded by sedation,<br> paralysis, hypoxia, hypotension, hypothermia, or concurrent medical illness<br><br> - Clinical evidence of disorder of consciousness defined as coma, VS, or MCS<br><br>Exclusion Criteria:<br><br> - History of prior severe brain injury or dementia<br><br> - Emergence from MCS at time of initial CRS-R assessment<br><br>Healthy Subjects:<br><br>Exclusion Criteria:<br><br>History of brain injury or neurological disease, psychiatric disease, or any history of<br>diabetes, high blood pressure, heart disease, or kidney disease

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Disability Rating Scale total score