Cracking Coma: towards EEG and MRI based precision medicine after cardiac arrest
Recruiting
- Conditions
- coma due to cardiac arresthypoxic coma1001928010014623
- Registration Number
- NL-OMON52980
- Lead Sponsor
- Rijnstate Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Comatose, defined as Glasgow Coma Score <= 8
Age >= 18 years
Cardiac arrest with a presumed cardiac cause of the arrest or caused by
lungembolism
Admission on ICU
Exclusion Criteria
Pregnancy
Life expectancy < 24 hours
Absence of written informed consent (by a legal representative)
Any known progressive brain illness, such as a brain tumor or neurodegenerative
disease.
Known contra-indication for MRI
Preexistente afhankelijkheid (CPC3-4)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure is neurological outcome, defined as the score on<br /><br>the Cerebral Performance Category (CPC) at six months, dichotomized as good<br /><br>(CPC 1-2 = no or moderate neurological disability) or poor (CPC 3-5 = severe<br /><br>disability, coma, or death)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcome measures include cognitive functioning, depression, and<br /><br>quality of life at one year, as well as histopathological damage of brain<br /><br>tissue of non-survivors.</p><br>