Is the Efficacy of Epidural Steroid Injections Related to the Different Volume Injections?
- Conditions
- Pain
- Interventions
- Registration Number
- NCT02343432
- Lead Sponsor
- Neslihan Uztüre
- Brief Summary
This study was aimed to investigate the impact of using different epidural volumes.
Patients with acute discogenic pain were included in the study.
- Detailed Description
Objectives: This study was aimed to investigate the impact of using different epidural volumes.
Methods: Seventy five patients with acute discogenic pain were included in the study.The patients were randomly assigned to three groups. All patients received a single epidural dose of triamcinolone \[80 mg\] and 12.5 mg bupivacaine combination. The patients in Group 1, Group 2 and Group 3 received a volume of 10 mL, 15 mL, and 20 mL by epidural injections, respectively. The efficacy of treatment was assessed with VAS (visual analog scale) \[O= no pain, 10 = unbearable pain\], SLET(straight leg elevation test) \[0° = worst, 85° = best\], and Oswestry Disability Index; ODI \[0% to 20%:minimal disability , 80% to 100%:bed bound patients\] before and 2 weeks after the EPSI.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- acute discogenic pain with less than three months duration not responding to other modalities of conservative management [NSAIDs, physiotherapy, bracing, etc.],
- radiological disc bulging accompanying unilateral root impingement symptoms,
- an Oswestry daily activity score more than 20 percent, and
- resistance to treatment.
- Patients with bilateral root impingement symptoms, neurological deficits, and/or history of previous lumbar disc surgery, severe cardiac, pulmonary, gastrointestinal, renal diseases, glaucoma, urinary retention, and/or known allergy to the drugs used in the study were excluded from the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Epidural Volume 15mL Epidural Volume Epidural Volume 15mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 15 mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 20mL Bupivacaine Epidural Volume 20mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 20 mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 10mL Triamcinolone Epidural Volume 10mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 10mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 15mL Bupivacaine Epidural Volume 15mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 15 mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 20mL Epidural Volume Epidural Volume 20mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 20 mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 10mL Epidural Volume Epidural Volume 10mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 10mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 10mL Bupivacaine Epidural Volume 10mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 10mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 15mL Triamcinolone Epidural Volume 15mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 15 mL Intervention: Drug: Bupivacaine 12.5mg Epidural Volume 20mL Triamcinolone Epidural Volume 20mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 20 mL Intervention: Drug: Bupivacaine 12.5mg
- Primary Outcome Measures
Name Time Method VAS (visual analog scale) [O= no pain, 10 = unbearable pain] 2 weeks Oswestry Disability Index; ODI [0% to 20%:minimal disability , 80% to 100%:bed bound patients] 2 weeks SLET(straight leg elevation test) [0° = worst, 85° = best] 2 weeks
- Secondary Outcome Measures
Name Time Method