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PHARMACOLOGY STUDY FOR EFFICACY OF TOPIRAMATE ASSOCIATED WITH HYPOTHERIMIA TREATMENT IN NEWBORNS WITH HYPOXIC ISCHEMIC ENCEPHALOPATY: A PILOT STUDY - HYPOTHERMIA AND TOPIRAMATE

Conditions
POST-ASPHYCTIC ENCEPHALOPATHY
MedDRA version: 9.1Level: SOCClassification code 10029205
Registration Number
EUCTR2010-018627-25-IT
Lead Sponsor
AZIENDA OSPEDALIERA MEYER
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Authorised-recruitment may be ongoing or finished
Sex
All
Target Recruitment
Not specified
Inclusion Criteria

MODERATE-SEVERE ASPHYXIA IN TERM NEWBORNS
Are the trial subjects under 18? yes
Number of subjects for this age range:
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

CONGENITAL ABNORMALITIES (CEREBRAL MALFORMATIONS)

Study & Design

Study Type
Interventional clinical trial of medicinal product
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Main Objective: TO EVALUATE THE POSSIBLE NEUROPROTECTIVE ADDITIVE EFFECT BETWEEN HYPOTHERMIA TREATMENT COMBINATED WITH ORAL TOPIRAMATE ADMINISTRATION: REDUCTION OF MORTALITY AND SEVERE NEUROLOGIC DISABILITY;Secondary Objective: PSYCHOMOTOR EVALUATION AT 18 MONTHS MULTIPLE DISABILITY;Primary end point(s): MORTALITY AND NEURODEVELOPMENT SCORE AT 18 MONTHS OF LIFE
Secondary Outcome Measures
NameTimeMethod
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