Reducing Costs by Deprescribing Medications

Not Applicable

Completed

• Conditions: Deprescribing; Polypharmacy; Adverse Drug Reaction
• Interventions: Behavioral: Deprescribing Intervention; Behavioral: Usual Care

• Registration Number: NCT04553107
• Lead Sponsor: The University of Texas Health Science Center, Houston

Brief Summary

The purpose of the study is to implement a pharmacist-led deprescribing intervention for adults 65 and older taking 10 or more medications at University of Texas (UT) Physicians clinics and to assess the effect of the pharmacist intervention on the incidence of adverse drug reactions, emergency room visits, and hospitalizations as well as costs to the patient and to the healthcare system in adults 65 and older taking 10 or more medications treated at UT Physicians.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-09
• Study First Submitted: 2020-09-11
• Study First Submitted QC: 2020-09-16
• Study First Posted: 2020-09-17
• Primary Completion: 2022-06-01
• Study Completion: 2022-06-01
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-21
• Last Update Posted: 2022-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 419

Inclusion Criteria

• taking 10 or more regular medications

Exclusion Criteria

• not receiving primary care at UT Physicians

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Deprescribing Intervention	Deprescribing Intervention	-
Usual Care	Usual Care	-

Primary Outcome Measures

Name	Time	Method
Adverse Drug Reactions	12 months post enrollment	Patient-reported side effects and adverse events potentially attributable to medication, rated for the likelihood of ADR by an independent reviewer based on the Naranjo algorithm.
Healthcare Cost	12 months post enrollment	Healthcare cost based on utilization of clinic visits, emergency room visits, and hospitalizations, based on patient report with specific costs obtained when possible from the Health Information Exchange.
Adverse Drug Reactions (ADR)	3 months post enrollment	Patient-reported side effects and adverse events potentially attributable to medication, rated for the likelihood of ADR by an independent reviewer based on the Naranjo algorithm.

Secondary Outcome Measures

Name	Time	Method
Medication cost	12 months post enrollment	Average wholesale price of each medication taken by a participant, determined using reference software.
Medication use	At enrollment	Number and name of each medication a participant is taking.
QOL	12 months post enrollment	Quality of life as measured by the EQ5D scale.This scale is numbered from 0 to 100. 100 means the best health you can imagine. 0 means the worst health you can imagine.

Trial Locations

Locations (1)

The University of Texas Health Science Center at Houston; 🇺🇸 Houston, Texas, United States