Cardiac magnetic resonance shows a different heart motion in healthy obese compared to normal-weight volunteers

Not Applicable

Completed

• Conditions: Cardiac remodeling; Circulatory System

• Registration Number: ISRCTN31812808
• Lead Sponsor: Charité - University Medicine Berlin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-04-30
• Study Start: 2021-06-10
• Last Update Posted: 20 June 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

1. Age >18 and <60 years
2. BMI >27 kg/m²
3. No medication except contraceptives or L-thyroxine
4. Discontinuation of a chronic medication must be medically justifiable because improvement in the condition for which the medication is being taken can be expected through weight loss

Exclusion Criteria

1. Pregnancy/lactation
2. Diseases or functional disorders that, in the opinion of the investigator, preclude participation in a clinical trial
3. Manifest endocrinological or metabolic diseases requiring treatment (diabetes mellitus, hypo- and hyperthyroidism, Cushing's syndrome, M. Cushing syndrome, Cushing's disease); normal TSH with L-thyroxine use is acceptable
4. Manifest cardiovascular diseases requiring treatment (hypertension like RR > 160/95 mmHg or > two medications; coronary artery disease or previous myocardial infarction; cerebral ischemia or apoplexy; clinically significant diseases of the blood vessels (stenoses of the vessels supplying the brain; renal artery stenoses, pAVK)
5. Diseases of the kidney, liver, or gastrointestinal tract that require treatment and intestinal tract that require chronic medication
6. Significant neurological or psychiatric disorders (depression, epilepsy, schizophrenia, bulimia nervosa)
7. History of bariatric surgery
8. Known or proven abuse of medication, drugs or alcohol
9. Tumor diseases; postoperative phase
10. Acute and chronic infections
11. Incapacity or circumstances that do not allow the patient to fully understand the nature, meaning, and implications of this study
12. Metal implants and other contraindications by performing MRI (body weight > 130 kg)

Study & Design

• Study Type: Observational
• Study Design: Not specified