Effect of Exercise on Renal Function in Predialysis

Phase 1

Completed

• Conditions: Chronic Kidney Disease
• Interventions: Other: Exercise

• Registration Number: NCT02155036
• Lead Sponsor: King's College Hospital NHS Trust

Brief Summary

The proposed research aims to examine whether regular aerobic exercise can preserve renal function, improve aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life. Ultimately, the research aims to prove that exercise is a more cost-effective and a more efficient use or healthcare resources used in the treatment of patients with CKD. Exercise is a relatively cheap treatment option which is readily available and accessible for this patient population. establish if, compared with usual care, an exercise programme for pre-dialysis CKD patients;

1. Preserves renal function.

2. Improves aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06
• Primary Completion: 2012-06
• Study Completion: 2012-06
• Study First Submitted: 2014-05-27
• Status Verified: 2014-06
• Study First Submitted QC: 2014-06-03
• Last Update Submitted: 2014-06-03
• Study First Posted: 2014-06-04
• Last Update Posted: 2014-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• • Stages 3-4 chronic kidney disease (CKD) patients (glomerular filtration rate (GFR) 20-60 mL/min)
• Male or female
• Aged >18 years
• Written informed consent

Exclusion Criteria

• Pregnancy

  • Requiring support for ambulation less than 20m
  • Vasculitis,
  • Proliferative diabetic retinopathy,
  • Severe osteodystrophy,
  • Uncontrolled diabetes,
  • Psychiatric illness, including anxiety, mood and untreated eating disorders
  • Infection or course of antibiotics within the last month

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	exercise intervention

Primary Outcome Measures

Name	Time	Method
kidney function	up to 12 months	estimated glomerular filtration rate (egfr) creatinine

Secondary Outcome Measures

Name	Time	Method
Body mass index (BMI)	Baseline, 6 and 12 months
Cardio-respiratory fitness testing (VO2peak)	Baseline, 6 and 12 months	cycle ergometer
Waist circumference	Baseline, 6 and 12 months
Duke's activity status index	Baseline, 6 and 12 months	questionnaire
Short Form 36 questionnaire	Baseline, 6 and 12 months
Total cholesterol	Baseline, 6 and 12 months
High sensitivity c-reactive protein (Hs CRP)	Baseline, 6 and 12 months
Blood pressure	Baseline, 6 and 12 months
Resting heart rate (HR)	Baseline, 6 and 12 months
Triglycerides	baseline, 6 and 12 months
Pulse Wave Velocity (arterial stiffness)	Baseline, 6 and 12 months	Vicorder equipment, carotid-femoral region.
weight	Baseline, 6 and 12 months

Trial Locations

Locations (1)

King's College Hospital; 🇬🇧 London, United Kingdom