NCT02155036已完成1 期
The Effect of Exercise on Renal Function and Cardiovascular Disease in Pre-dialysis (Chronic Kidney Disease Stage 3-4) Patients With Chronic Kidney Disease; a Randomised Controlled Trial Pilot Study.
King's College Hospital NHS Trust2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2011年6月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- kidney function
研究概览
简要总结
The proposed research aims to examine whether regular aerobic exercise can preserve renal function, improve aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life. Ultimately, the research aims to prove that exercise is a more cost-effective and a more efficient use or healthcare resources used in the treatment of patients with CKD. Exercise is a relatively cheap treatment option which is readily available and accessible for this patient population. establish if, compared with usual care, an exercise programme for pre-dialysis CKD patients;
- Preserves renal function.
- Improves aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Stages 3-4 chronic kidney disease (CKD) patients (glomerular filtration rate (GFR) 20-60 mL/min)
- •Male or female
- •Aged >18 years
- •Written informed consent
排除标准
- •Pregnancy
- •Requiring support for ambulation less than 20m
- •Vasculitis,
- •Proliferative diabetic retinopathy,
- •Severe osteodystrophy,
- •Uncontrolled diabetes,
- •Psychiatric illness, including anxiety, mood and untreated eating disorders
- •Infection or course of antibiotics within the last month
结局指标
主要结局
kidney function
时间窗: up to 12 months
estimated glomerular filtration rate (egfr) creatinine
次要结局
- Body mass index (BMI)(Baseline, 6 and 12 months)
- Cardio-respiratory fitness testing (VO2peak)(Baseline, 6 and 12 months)
- Waist circumference(Baseline, 6 and 12 months)
- Duke's activity status index(Baseline, 6 and 12 months)
- Short Form 36 questionnaire(Baseline, 6 and 12 months)
- Total cholesterol(Baseline, 6 and 12 months)
- High sensitivity c-reactive protein (Hs CRP)(Baseline, 6 and 12 months)
- Blood pressure(Baseline, 6 and 12 months)
- Resting heart rate (HR)(Baseline, 6 and 12 months)
- Triglycerides(baseline, 6 and 12 months)
- Pulse Wave Velocity (arterial stiffness)(Baseline, 6 and 12 months)
- weight(Baseline, 6 and 12 months)
研究者
研究点 (2)
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