A clinical trial to compare the effects of 0.5% Ropivacaine with 1mL (0.3mg) Buprenorphine versus 0.5% Ropivacaine with 1mL Normal saline while giving Supraclavicular brachial plexus block for upper limb orthopaedic surgeries.

Phase 4

Not yet recruiting

Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical,

Registration Number: CTRI/2022/06/043277

Lead Sponsor: Mrigakshi Sarma

Brief Summary: Techniques of regional anaesthesia provide advantages over general anaesthesia. Supraclavicular brachial plexus block is the single most effective block for entire upper extremity and provides anaesthesia of all portions of upper extremity. To overcome the brief duration of action of local anaesthetics and to prolong intraoperative anaesthesia and postoperative analgesia many opioids have been tried with local anaesthetics.Ropivacaine, a local anaesthetic having wider safety margin, with decreased potential for central nervous system toxicity and cardiotoxicity, improves relative sensory and motor block profiles. Buprenorphine a semisynthetic opioid with longer duration of action cost effective and possess lesser degree of side effects such as sedation and respiratory depression.

REFERENCES

1.Jain N, Khare A, Khandelwal S, Mathur P, Singh M, Mathur V. Buprenorphine as an adjuvant to 0.5% Ropivacaine for ultrasound guided supraclavicular brachial plexus block: a randomized ,double-blind, prospective study. Indian J Pain[serial online] 2017[cited 2021Apr 1];31:112-8

2.Editorial Anaesthesia UK. Does regional anaesthesia improve outcome 2017. Available from http://www.frca.co.uk/article.aspx?articleid=100457.[Last cited on 2017 Apr15]

3.Brown DL. Brachial plexus anesthesia: an analysisof options. Yale J Biol Med. 1993 Sep-Oct;66(5):415-31

4.Patil S, Debata D, Doshi C, Vyas V, Sinha S. Effect of Buprenorphine as an adjunct with plain local anesthetic solution in supraclavicular brachial plexus block on quality and duration of postoperative analgesia. J Anaesthesiol Clin Pharmacol. 2015 Oct-Dec;31(4):496-500.

5.Paramaswamy R, Sabarinath S. Comparison of effect of 0.5% ropivacaine with fentanyl versus 0.5%ropivacaine with buprenorphine in axillary brachial plexus blocks for isolated hand and forearm injuries. Int J Med Anesthesiology 2020;3(1):16-22..

6.Kuthiala G, Chaudhary G. Ropivacaine :A review of its pharmacology and clinical use. Indian J Anaesth 2011;55:104-10

7.Vadivelu N, Anwar M. Buprenorphine in postoperative pain management. Anesthesiol Clin. 2010 Dec; 28(4):601-9

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 64

Inclusion Criteria

American Society of Anaesthesiology(ASA) physical status I and II.
2.Scheduled for elective Orthopaedic upper limb surgery under supraclavicular brachial plexus block.
Informed and written consent.

Exclusion Criteria

1.Unwilling patients.
2.Patients belonging to ASA physical status III or more.
Patients with known hypersensitivity to local anaesthetics.
4.Infection at the site of block.
5.Patients with known coagulopathy or patients on anticoagulation therapy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the duration of post operative analgesia by addition of injection buprenorphine to 0.5% Ropivacaine solution.	After completion of the block to next 24hours.

Secondary Outcome Measures

Name	Time	Method
1.Sensory block onset time.	2.Motor block onset time.

Trial Locations

Locations (1): Gauhati Medical College and Hospital
🇮🇳
Kamrup, ASSAM, India
Gauhati Medical College and Hospital
🇮🇳Kamrup, ASSAM, India
Dr Mrigakshi Sarma
Principal investigator
9707590744
mrigakshisarma93@gmail.com