Efficacy of detecting orthodontic root resorption

Phase 2/3

Not yet recruiting

Conditions: No pathological root resorption
Pathological resorption of teeth,

Registration Number: CTRI/2024/01/061380

Lead Sponsor: Rebekah Raju

Brief Summary: Root resorption is an unfavourable sequelae in orthodontic treatment. It is referred to as orthodontically induced root resorption (OIRR) . One of the major factors causing OIRR includes the orthodontic treatment techniques such as magnitude, duration and type of orthodontic force application. Early detection of teeth at risk of severe resorption is crucial . Currently, using radiographs is common; however, they are technique sensitive and cannot indicate if the process of root resorption is still active . This also leads to additional radiation exposure to the patients. Therefore, a safer, more reliable alternative method to clinically diagnose early stages of root resorption is much needed and may include detecting specific biomarkers in gingival crevicular fluid.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

Adult subjects aged 18 to 30 years with no congenital anomalies, systemic diseases, missing teeth, or a history of previous orthodontic treatment requiring malocclusion correction.

Exclusion Criteria

Subjects below the age group of 18 years and above the age group of 30 years, with congenital anomalies, systemic diseases, missing teeth, or a history of previous orthodontic treatment.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate changes in the Dentin Sialophosphoprotein biomarker levels between study & control groups	For a period of 12 weeks

Secondary Outcome Measures

Name	Time	Method
To evaluate root resorption craters before & after orthodontic intrusive forces.

Trial Locations

Locations (1): Saveetha Dental College and Hospital
🇮🇳
Chennai, TAMIL NADU, India
Saveetha Dental College and Hospital
🇮🇳Chennai, TAMIL NADU, India
Rebekah
Principal investigator
9789822573
152108001.sdc@saveetha.com