Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder. - Disrupting the rhythm of depression

niversitair Medisch Centrum Groningen0 个研究点目标入组 276 人开始时间: 待定最近更新: 2024年8月26日

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•Patients with major depressive disorder (DSM-IV) with at least two previous depressive episodes in the past five years.
•Last episode was treated succesfully with an antidepressant and the patient is still using that antidepressant at an adequate dose (recommended minimum dose according to Farmacotherapeutisch Kompas.
•Currently in remission according to DSM-IV criteria, for at least 8 weeks and no longer than 2 years.
•A current score of <10 in the Hamilton Rating Scale for Depression (HRSD).;New addition on 30-7-2012
•All included participants are able to particpate in the additional study with the exception of women with a current pregnancy or recent delivery (<6 months); in case of doubt the woman will not be included.

•* Bipolar I of bipolar II disorder (indicated by previous or current manic or hypomanic episode (DSM-IV)
•* serious neurological or somatic disorder (including organic brain damage) as possible cause of depression
•* alcohol or drug abuse during the last six months; alcohol or drug dependence during two years
•* comorbid anxiety disorder, necessitating additional treatment
•* ongoing or recent (<6 months) psychotherapy (CT, CBT, IPT, etcetera) with a frequency of more than two times a month.

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